Iron is an essential nutrient required for a variety of biochemical processes. It is a vital
component of the heme in hemoglobin, myoglobin, and cytochromes and is also an …

Iron is ubiquitous in the environment and in biology. The study of iron biology focuses on
physiology and homeostasis—understanding how cells and organisms regulate their iron …

Handling a life‐supporting yet redox‐active metal like iron represents a significant challenge
to cells and organisms that must not only tightly balance intra‐and extracellular iron …

Iron is a crucial factor for life. However, it also has the potential to cause the formation of
noxious free radicals. These double-edged sword characteristics demand a tight regulation …

Iron is vital for almost all living organisms by participating in a wide variety of metabolic
processes, including oxygen transport, DNA synthesis, and electron transport. However, iron …

Iron is vital for almost all organisms because of its ability to donate and accept electrons with
relative ease. It serves as a cofactor for many proteins and enzymes necessary for oxygen …

Regulation of both systemic and cellular iron homeostasis requires the capacity to sense
iron levels and appropriately modify the expression of iron metabolism genes. These …

Iron is an essential element that is toxic when it accumulates in excess. Intricate regulatory
mechanisms have evolved to maintain iron homeostasis within cells and between different …

Although iron is a relatively abundant element in the universe, it is estimated that more than
2 billion people worldwide suffer from iron deficiency anemia. Iron deficiency results in …

Iron is needed by all mammalian cells but is toxic in excess. Specialized transport
mechanisms conduct iron across cellular membranes. These are regulated to ensure …