Rationale Rats develop preferences for places associated with the immediate rewarding
effects of cocaine and aversions for places paired with the drug's delayed negative effects …

Rationale The place conditioning procedure is increasingly used to study relapse in drug
seeking in mice. However, the retention course of drug-induced place preference has not …

Rats allowed extended access to cocaine self-administration develop a number of
symptoms of addiction, such as greater susceptibility to drug-induced relapse. Using the …

Reinstatement of drug-seeking behavior in animals is relevant to drug relapse in humans. In
the present study, we employed the conditioned place preference (CPP) paradigm to …

Alcohol has been reported to modulate the reinforcing and aversive properties of cocaine.
Given these effects, the present study examined whether this interaction could be extended …

To explore the way in which drugs act to reinstate drug-seeking behavior, we studied drug-
induced reinstatement of a cocaine-induced conditioned place preference (CPP). In a series …

Rationale Drug addiction is a multifactorial disorder resulting from an interaction between
genetic and environmental factors, and negative and positive environmental conditions may …

Rationale Disruption of acquired drug–cue associations can effectively decrease relapse.
The benefits of extinction training as opposed to abstinence have been reported. Timing of …

The rewarding effect of cocaine as reflected by the development of conditioned place
preference was examined in C57BL/6J and 129/J mice. Cocaine was administered in a …

To explore sex differences in reinstatement of conditioned place preference, we subjected
intact male and female Long Evans rats to an extended conditioned place preference (CPP) …