Genetics of complex respiratory diseases: implications for pathophysiology and pharmacology studies

M Obeidat, IP Hall - British journal of pharmacology, 2011 - Wiley Online Library
There has been a huge influx of data on the genetics and genomics of respiratory diseases
in the last few years. Powered by large sample sizes from collaborations worldwide, recent …

Pharmacogenetics and asthma: false hope or new dawn?

IP Hall, I Sayers - European Respiratory Journal, 2007 - Eur Respiratory Soc
Pharmacogenetic approaches provide the opportunity to improve prescribing for asthmatic
patients in order to optimise efficacy and prevent side-effects. Currently, there are …

Genetics of chronic respiratory disease

I Sayers, C John, J Chen, IP Hall - Nature Reviews Genetics, 2024 - nature.com
Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD),
asthma and interstitial lung diseases are frequently occurring disorders with a polygenic …

What genes tell us about the pathogenesis of asthma and chronic obstructive pulmonary disease

ST Weiss - American journal of respiratory and critical care …, 2010 - atsjournals.org
Recently a series of genome-wide association study manuscripts in asthma and chronic
obstructive pulmonary disease have been published. These papers suggest that, in part …

Genetics of complex airway disease

WOC Cookson, MF Moffatt - Proceedings of the American Thoracic …, 2011 - atsjournals.org
The past 3 years have seen highly significant genetic effects identified for a wide variety of
common complex diseases, including the airway disorders of asthma and chronic …

Genetic risk factors for the development of pulmonary disease identified by genome‐wide association

R Hall, IP Hall, I Sayers - Respirology, 2019 - Wiley Online Library
Chronic respiratory diseases are a major cause of morbidity and mortality. Asthma and
chronic obstructive pulmonary disease (COPD) combined affect over 500 million people …

Shared genetic aetiology of respiratory diseases: a genome-wide multitraits association analysis

Z Chen, N Gao, X Wang, X Chen… - BMJ Open …, 2024 - bmjopenrespres.bmj.com
Objective This study aims to explore the common genetic basis between respiratory
diseases and to identify shared molecular and biological mechanisms. Methods This …

Recent development in genomic and proteomic research for asthma

E Halapi, H Hakonarson - Current opinion in pulmonary medicine, 2004 - journals.lww.com
The asthma genetics field has advanced considerably in recent years, with new information
being generated that has led to improved understanding of the pathobiology underlying this …

[PDF][PDF] Respiratory medicine–genetic base for allergy and asthma

A Binia, M Kabesch - Swiss medical weekly, 2012 - smw.ch
Allergy and asthma are complex diseases influenced by many genes and molecular
mechanisms. Recently a number of genome-wide association studies (GWAS) have …

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

LV Wain, N Shrine, MS Artigas, AM Erzurumluoglu… - Nature …, 2017 - nature.com
Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function
and is the third leading cause of death globally. Through genome-wide association …