Mitochondrial dysfunction contributes to the pathogenesis of Alzheimer's disease

FA Cabezas-Opazo, K Vergara-Pulgar… - Oxidative medicine …, 2015 - Wiley Online Library
Alzheimer's disease (AD) is a neurodegenerative disease that affects millions of people
worldwide. Currently, there is no effective treatment for AD, which indicates the necessity to …

[HTML][HTML] Mitochondrial dysfunction and oxidative stress in Alzheimer's disease

A Misrani, S Tabassum, L Yang - Frontiers in aging neuroscience, 2021 - frontiersin.org
Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …

Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: Recent advances

W Wang, F Zhao, X Ma, G Perry, X Zhu - Molecular neurodegeneration, 2020 - Springer
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases,
characterized by impaired cognitive function due to progressive loss of neurons in the brain …

Alzheimer's pathogenesis and its link to the mitochondrion

C Simoncini, D Orsucci… - Oxidative medicine …, 2015 - Wiley Online Library
Alzheimer's disease (AD) is the most common form of dementia in the elderly. This
neurodegenerative disorder is clinically characterized by impairment of cognitive functions …

Mitochondrial cascade hypothesis of Alzheimer's disease: myth or reality?

M Mancuso, F Coppedè, L Murri… - Antioxidants & redox …, 2007 - liebertpub.com
Mitochondria are recognized to play a pivotal role in neuronal cell survival or death because
they are regulators of both energy metabolism and apoptotic pathways. Morphologic …

[HTML][HTML] Relationships between mitochondrial dysfunction and neurotransmission failure in Alzheimer's disease

KY Wong, J Roy, ML Fung, BC Heng, C Zhang… - Aging and …, 2020 - ncbi.nlm.nih.gov
Besides extracellular deposition of amyloid beta and formation of phosphorylated tau in the
brains of patients with Alzheimer's disease (AD), the pathogenesis of AD is also thought to …

Mitochondrial dysfunction: a potential therapeutic target to treat Alzheimer's disease

SN Rai, C Singh, A Singh, MP Singh, BK Singh - Molecular Neurobiology, 2020 - Springer
Mitochondrial dysfunction plays a very vital role in the pathogenesis of Alzheimer's disease
(AD). Several shreds of evidence have indicated that the mitochondrial function is severely …

Mitochondrial dysfunction: common final pathway in brain aging and Alzheimer's disease—therapeutic aspects

WE Müller, A Eckert, C Kurz, GP Eckert… - Molecular neurobiology, 2010 - Springer
As a fully differentiated organ, our brain is very sensitive to cumulative oxidative damage of
proteins, lipids, and DNA occurring during normal aging because of its high energy …

Mechanisms of mitochondrial dysfunction in Alzheimer's disease

C Cadonic, MG Sabbir, BC Albensi - Molecular neurobiology, 2016 - Springer
Mitochondria are the primary source for energy generation in the cell, which manifests itself
in the form of the adenosine triphosphate (ATP). Nicotinamide dinucleotide (NADH) …

The role of mitochondrial dysfunction in Alzheimer's disease: a potential pathway to treatment

AB Reiss, S Ahmed, C Dayaramani, AD Glass… - Experimental …, 2022 - Elsevier
Background Alzheimer's disease (AD) is the most prevalent form of dementia worldwide and
is characterized by progressive memory loss and cognitive impairment. Our understanding …