The significance and regulatory mechanisms of innate immune cells in the development of sepsis

YY Luan, N Dong, M Xie, XZ Xiao… - Journal of Interferon & …, 2014 - liebertpub.com
Sepsis with subsequent multiple organ dysfunction is a pronounced systemic inflammatory
response to concealed or known infection and is a leading cause of death in intensive care …

Inflammation and cell death of the innate and adaptive immune system during sepsis

C Nedeva - Biomolecules, 2021 - mdpi.com
Sepsis is a life-threatening medical condition that occurs when the host has an uncontrolled
or abnormal immune response to overwhelming infection. It is now widely accepted that …

The immune system regulation in sepsis: from innate to adaptive

Y Qiu, G Tu, M Ju, C Yang, Z Luo - Current Protein and Peptide …, 2019 - ingentaconnect.com
Sepsis, which is a highly heterogeneous syndrome, can result in death as a consequence of
a systemic inflammatory response syndrome. The activation and regulation of the immune …

Role of cellular events in the pathophysiology of sepsis

C Bhan, P Dipankar, P Chakraborty, PP Sarangi - Inflammation research, 2016 - Springer
Introduction Sepsis is a dysregulated host immune response due to an uncontrolled
infection. It is a leading cause of mortality in adult intensive care units globally. When the …

Innate immunity in sepsis pathogenesis and its modulation: new immunomodulatory targets revealed

V Kumar, A Sharma - Journal of chemotherapy, 2008 - Taylor & Francis
Sepsis is complex clinical manifestation of an organism's overwhelming and unregulated
immune response to infection. Despite more than 25 years of extensive re search, sepsis …

Current trends in inflammatory and immunomodulatory mediators in sepsis

M Aziz, A Jacob, WL Yang, A Matsuda… - Journal of leukocyte …, 2013 - academic.oup.com
Review on sepsis mediators, and roles in innate and adaptive immune systems, as well as
implications for therapeutics. Sepsis refers to severe systemic inflammation in response to …

Innate lymphoid cells: Potent early mediators of the host immune response during sepsis

M Theertha, S Sanju, VV Priya, P Jain… - Cellular & molecular …, 2020 - nature.com
Sepsis is a life-threatening syndrome caused by a dysregulated host response to infection,
resulting in very high mortality. Dysfunction of the tightly regulated immune response occurs …

In search of a cure for sepsis: taming the monster in critical care medicine

EB Okeke, JE Uzonna - Journal of Innate Immunity, 2016 - karger.com
In spite of over half a century of research, sepsis still constitutes a major problem in health
care delivery. Although advances in research have significantly increased our knowledge of …

Sepsis: rethinking the approach to clinical research

JC Marshall - Journal of Leucocyte Biology, 2008 - academic.oup.com
The clinical syndrome of sepsis encompasses a highly heterogeneous group of clinical
disorders, varying with respect to the site, bacteriology, and even presence of infection and …

[HTML][HTML] Sepsis and nosocomial infection: patient characteristics, mechanisms, and modulation

SJ Denstaedt, BH Singer, TJ Standiford - Frontiers in Immunology, 2018 - frontiersin.org
Sepsis is a leading cause of death worldwide. After initial trials modulating the
hyperinflammatory phase of sepsis failed, generations of researchers have focused on …