With the conceptual advance about four decades ago that type 1 diabetes represents an
autoimmune disease, hope arose that immune-based therapies would soon emerge to …

Lupus nephritis (LN) is one of the most common manifestations of systemic lupus
erythematosus (SLE), characterized by abnormal B cell activation and differentiation to …

Type 1 diabetes results from the destruction of insulin-producing pancreatic β cells by a β
cell-specific autoimmune process. β Cell autoantigens, macrophages, dendritic cells, B …

Accumulating data from animal models of type 1 diabetes and some findings from clinical
studies suggest that autoimmune destruction of islet β cells is associated with enhanced β …

Background/Aims: Recent evidence has shown that an inflammatory process is involved in
the development and progression of diabetic nephropathy. This study examined the impact …

The role of B lymphocytes in the pathogenesis of type 1 diabetes in humans is not entirely
evident. These cells are presumed to be important, but this assumption is largely based on …

Type 1 diabetes (T1D) results from the progressive destruction of pancreatic β-cells in a
process mediated primarily by T lymphocytes. The T1D research community has made …

T cell-directed immunosuppression only transiently delays the loss of β cell function in
recent-onset type 1 diabetes. We argue here that the underlying disease process is carried …

Diabetic kidney disease (DKD) is a highly prevalent complication of diabetes and the
leading cause of end‐stage kidney disease. Inflammation is recognized as an important …

In type 1 diabetes, cytotoxic CD8+ T cells with specificity for β cell autoantigens are found in
the pancreatic islets, where they are implicated in the destruction of insulin-secreting β cells …