[HTML][HTML] A polymorphic helix of a Salmonella needle protein relays signals defining distinct steps in type III secretion

EZ Guo, DC Desrosiers, J Zalesak, J Tolchard… - PLoS …, 2019 - journals.plos.org
Type III protein-secretion machines are essential for the interactions of many pathogenic or
symbiotic bacterial species with their respective eukaryotic hosts. The core component of …

The inner rod protein controls substrate switching and needle length in a Salmonella type III secretion system

MD Lefebre, JE Galán - Proceedings of the National …, 2014 - National Acad Sciences
Type III secretion machines are essential for the biology of many bacteria that are
pathogenic or symbiotic for animals, plants, or insects. They exert their function by delivering …

Cryo-EM structure of the needle filament tip complex of the Salmonella type III secretion injectisome

EZ Guo, JE Galán - … of the National Academy of Sciences, 2021 - National Acad Sciences
Type III secretion systems are multiprotein molecular machines required for the virulence of
several important bacterial pathogens. The central element of these machines is the …

[HTML][HTML] Topology and Organization of the Salmonella typhimurium Type III Secretion Needle Complex Components

O Schraidt, MD Lefebre, MJ Brunner… - PLoS …, 2010 - journals.plos.org
The correct organization of single subunits of multi-protein machines in a three dimensional
context is critical for their functionality. Type III secretion systems (T3SS) are molecular …

[HTML][HTML] A protein secreted by the Salmonella type III secretion system controls needle filament assembly

J Kato, S Dey, JE Soto, C Butan, MC Wilkinson… - Elife, 2018 - elifesciences.org
Type III protein secretion systems (T3SS) are encoded by several pathogenic or symbiotic
bacteria. The central component of this nanomachine is the needle complex. Here we show …

Molecular ruler determines needle length for the Salmonella Spi-1 injectisome

DH Wee, KT Hughes - … of the National Academy of Sciences, 2015 - National Acad Sciences
The type-III secretion (T3S) systems of bacteria are part of self-assembling nanomachines:
the bacterial flagellum that enables cells to propel themselves through liquid and across …

Salmonella type III secretion effectors: pulling the host cell's strings

MC Schlumberger, WD Hardt - Current opinion in microbiology, 2006 - Elsevier
The enteric pathogen Salmonella employs type III secretion systems to transport a cocktail of
effector proteins directly into its host cell. These effectors act in concert to control a variety of …

NMR identification of the binding surfaces involved in the Salmonella and Shigella Type III secretion tip‐translocon protein–protein interactions

AC McShan, K Kaur, S Chatterjee… - Proteins: Structure …, 2016 - Wiley Online Library
The type III secretion system (T3SS) is essential for the pathogenesis of many bacteria
including Salmonella and Shigella, which together are responsible for millions of deaths …

[HTML][HTML] In situ molecular architecture of the Salmonella type III secretion machine

B Hu, M Lara-Tejero, Q Kong, JE Galán, J Liu - Cell, 2017 - cell.com
Type III protein secretion systems have specifically evolved to deliver bacterially encoded
proteins into target eukaryotic cells. The core elements of this multi-protein machine are the …

Genetic Analysis of Assembly of theSalmonella enterica Serovar Typhimurium Type III Secretion-Associated Needle Complex

A Sukhan, T Kubori, J Wilson, JE Galán - Journal of bacteriology, 2001 - Am Soc Microbiol
Several pathogenic bacteria have evolved a specialized protein secretion system termed
type III to secrete and deliver effector proteins into eukaryotic host cells. Salmonella enterica …