Osteoarthritis: New insight on its pathophysiology
Understanding of the basis of osteoarthritis (OA) has seen some interesting advancements
in recent years. It has been observed that cartilage degeneration is preceded by …
in recent years. It has been observed that cartilage degeneration is preceded by …
Bone–cartilage crosstalk: a conversation for understanding osteoarthritis
DM Findlay, JS Kuliwaba - Bone research, 2016 - nature.com
Although cartilage degradation is the characteristic feature of osteoarthritis (OA), it is now
recognized that the whole joint is involved in the progression of OA. In particular, the …
recognized that the whole joint is involved in the progression of OA. In particular, the …
Osteoarthritis: toward a comprehensive understanding of pathological mechanism
Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …
[HTML][HTML] Current concepts in the pathogenesis of osteoarthritis
S Krasnokutsky, M Attur, G Palmer, J Samuels… - Osteoarthritis and …, 2008 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease that progressively causes loss of joint
function and is the leading source of physical disability and impaired quality of life in …
function and is the leading source of physical disability and impaired quality of life in …
[HTML][HTML] Interplay between cartilage and subchondral bone contributing to pathogenesis of osteoarthritis
Osteoarthritis (OA) is a common debilitating joint disorder, affecting large sections of the
population with significant disability and impaired quality of life. During OA, functional units …
population with significant disability and impaired quality of life. During OA, functional units …
Molecular mechanisms of cartilage remodelling in osteoarthritis
J Bertrand, C Cromme, D Umlauf, S Frank… - The international journal …, 2010 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease that is characterized primarily by
progressive breakdown of articular cartilage. The loss of proteoglycans, the mineralization of …
progressive breakdown of articular cartilage. The loss of proteoglycans, the mineralization of …
Mechanisms of joint destruction in rheumatoid arthritis—immune cell–fibroblast–bone interactions
N Komatsu, H Takayanagi - Nature Reviews Rheumatology, 2022 - nature.com
Rheumatoid arthritis (RA) is characterized by inflammation and destruction of bone and
cartilage in affected joints. Autoimmune responses lead to increased osteoclastic bone …
cartilage in affected joints. Autoimmune responses lead to increased osteoclastic bone …
Emerging targets in osteoarthritis therapy
MB Goldring, F Berenbaum - Current opinion in pharmacology, 2015 - Elsevier
Highlights•Different OA etiologies present a challenge for developing a single targeted
therapy.•Common mechanisms occur in inflammatory, mechanical, and oxidative stress in …
therapy.•Common mechanisms occur in inflammatory, mechanical, and oxidative stress in …
Is osteoarthritis a disease involving only cartilage or other articular tissues?
J Martel-Pelletier, JP Pelletier - Eklem hastaliklari ve cerrahisi= Joint …, 2010 - europepmc.org
Osteoarthritis (OA) is a progressive and disabling disease resulting from a combination of
risk factors, including advancing age, genetics, trauma, knee malalignment, increased …
risk factors, including advancing age, genetics, trauma, knee malalignment, increased …
Update on the biology of the chondrocyte and new approaches to treating cartilage diseases
MB Goldring - Best practice & research Clinical rheumatology, 2006 - Elsevier
Osteoarthritis (OA) is a joint disease that involves degeneration of articular cartilage, limited
intraarticular inflammation manifested by synovitis and changes in the subchondral bone …
intraarticular inflammation manifested by synovitis and changes in the subchondral bone …