Highlights•Osteoarthritis (OA) is a common and debilitating disease with no effective
treatments.•Articular chondrocyte behavior and matrix maintenance are major targets.•The …

Osteoarthritis (OA) is one of the most common diseases among the elderly. For many years,
OA was considered a normal result of the aging process with few treatment options …

The rising prevalence of osteoarthritis (OA) in the general population has necessitated the
development of novel treatment options. It is critical to recognize the joint as a separate …

Subchondral bone and the synovium play an important role in the initiation and progression
of OA. MRI often permits an early detection of synovial hypertrophy and bone marrow …

One central hallmark of osteoarthritic cartilage degeneration is the loss of matrix molecules,
in particular proteoglycans. However, chondrocytes of osteoarthritic cartilage are generally …

Destruction and loss of articular cartilage is a central feature in most forms of arthritis
including the most common form, osteoarthritis (OA). The pathobiologic differences among …

Bone remodeling in physiological and pathological conditions represents a balance
between bone resorption mediated by osteoclasts and bone formation by osteoblasts. Bone …

Human osteoarthritis is a systemic musculoskeletal disorder involving activation of innate
and adaptive immune systems accompanied by inflammation exemplified by the elevated …

Background Rheumatoid arthritis (RA) is a chronic, inflammatory and systemic autoimmune
disease that leads to progressive cartilage destruction. Advances in the treatment of RA …

Rheumatoid arthritis (RA) is recognized to be an autoimmune disease that causes
preclinical systemic abnormalities and eventually leads to synovial inflammation and …