Drug delivery systems from nose to brain

A Misra, G Kher - Current pharmaceutical biotechnology, 2012 - ingentaconnect.com
The treatment of brain disorders is particularly challenging due to the presence of a variety
of formidable obstacles to deliver drugs selectively and effectively to the brain. Blood-brain …

Recent patents review on intranasal administration for CNS drug delivery

A Misra, V Jogani, K Jinturkar… - Recent patents on drug …, 2008 - ingentaconnect.com
The treatment of brain disorders is the greatest challenge because of a variety of formidable
obstacles in effective drug delivery and maintaining therapeutic concentrations in the brain …

Nose-to-brain drug delivery: challenges and progress towards brain targeting in the treatment of neurological disorders

M Raghav, V Gupta, R Awasthi, A Singh… - Journal of Drug Delivery …, 2023 - Elsevier
Delivery of therapeutics to the central nervous system for treating psychiatric and
neurodegenerative disorders, such as Parkinson's disease and Alzheimer's disease, is a …

Intranasal drug delivery for brain targeting

TK Vyas, A Shahiwala, S Marathe… - Current drug delivery, 2005 - ingentaconnect.com
Many drugs are not being effectively and efficiently delivered using conventional drug
delivery approach to brain or central nervous system (CNS) due to its complexity. The brain …

Insights into direct nose to brain delivery: current status and future perspective

D Mittal, A Ali, S Md, S Baboota, JK Sahni, J Ali - Drug delivery, 2014 - Taylor & Francis
Now a day's intranasal (in) drug delivery is emerging as a reliable method to bypass the
blood–brain barrier (BBB) and deliver a wide range of therapeutic agents including both …

Drug delivery to the brain via the nasal route of administration: exploration of key targets and major consideration factors

SH Jeong, JH Jang, YB Lee - Journal of pharmaceutical investigation, 2023 - Springer
Background Cranial nerve-related diseases such as brain tumors, Alzheimer's disease, and
epilepsy are serious diseases that continue to threaten human. Brain-related diseases are …

Formulation and physiological factors influencing CNS delivery upon intranasal administration

T Vyas, SB Tiwari, MM Amiji - Critical Reviews™ in Therapeutic …, 2006 - dl.begellhouse.com
The treatment of central nervous system (CNS) disorders is particularly challenging because
of a variety of formidable barriers to effective and persistent delivery of therapeutic …

[PDF][PDF] Nose to brain targeted drug delivery bypassing the blood-brain barrier: an overview.

Z Patel, B Patel, S Patel, C Pardeshi - Drug Invention Today, 2012 - academia.edu
Present review highlights the potential of nasal mucosa as an administration route for
targeting the central nervous system (CNS), in particular, the brain. Delivery of drugs to the …

Drug delivery and targeting to the brain through nasal route: mechanisms, applications and challenges

K Kashyap, R Shukla - Current drug delivery, 2019 - ingentaconnect.com
Blood-brain barrier (BBB) provides restrictions for the transportation of various therapeutic
agents to the brain. Efforts to directly target the brain by olfactory as well as trigeminal nerve …

Intranasal drug delivery: a novel approach

Y Chugh, P Kapoor, AK Kapoor - Indian Journal of Otolaryngology …, 2009 - ncbi.nlm.nih.gov
Intranasal drug delivery occupies the prime place against newer drug delivery systems to
transport drugs to CNS bypassing the blood brain barrier. Recent advances in molecular …