Hepatitis C virus (HCV) entry is dependent on CD81. To investigate whether the CD81
sequence is a determinant of HCV host range, we expressed a panel of diverse CD81 …

ABSTRACT CD81 has been described as a putative receptor for hepatitis C virus (HCV);
however, its role in HCV cell entry has not been characterized due to the lack of an efficient …

Recently a cell culture model supporting the complete life cycle of the hepatitis C virus
(HCV) was developed. Searching for host cell determinants involved in the HCV replication …

We recently reported that retroviral pseudotypes bearing the hepatitis C virus (HCV) strain H
and Con1 glycoproteins, genotype 1a and 1b, respectively, require CD81 as a coreceptor for …

Hepatitis C virus (HCV) cell entry involves interaction between the viral envelope
glycoprotein E2 and the cell surface receptor CD81. Knowledge of conserved E2 …

Hepatitis C virus (HCV) is a major human pathogen causing chronic liver disease. We have
recently found that the large extracellular loop (LEL) of human CD81 binds HCV. This …

We previously demonstrated that hepatitis C virus (HCV) binds to human CD81 through the
E2 glycoprotein. Therefore, expression of the human CD81 molecule in transgenic mice was …

The mechanisms of hepatitis C virus (HCV) replication remain poorly understood, and the
cellular factors required for HCV replication are yet to be completely defined. CD81 is known …

CD81 is a required receptor for hepatitis C virus (HCV) infection of human hepatocytes in
vitro. We generated several high‐affinity anti‐human CD81 monoclonal antibodies (mAbs) …

Hepatitis C virus (HCV) envelope glycoproteins E1/E2 can pseudotype retroviral particles
and efficiently mediate entry into target cells. Using this experimental system, we determined …