Diverse CD81 proteins support hepatitis C virus infection
M Flint, T von Hahn, J Zhang, M Farquhar… - Journal of …, 2006 - Am Soc Microbiol
Hepatitis C virus (HCV) entry is dependent on CD81. To investigate whether the CD81
sequence is a determinant of HCV host range, we expressed a panel of diverse CD81 …
sequence is a determinant of HCV host range, we expressed a panel of diverse CD81 …
CD81 is required for hepatitis C virus glycoprotein-mediated viral infection
ABSTRACT CD81 has been described as a putative receptor for hepatitis C virus (HCV);
however, its role in HCV cell entry has not been characterized due to the lack of an efficient …
however, its role in HCV cell entry has not been characterized due to the lack of an efficient …
The level of CD81 cell surface expression is a key determinant for productive entry of hepatitis C virus into host cells
G Koutsoudakis, E Herrmann, S Kallis… - Journal of …, 2007 - Am Soc Microbiol
Recently a cell culture model supporting the complete life cycle of the hepatitis C virus
(HCV) was developed. Searching for host cell determinants involved in the HCV replication …
(HCV) was developed. Searching for host cell determinants involved in the HCV replication …
Diverse hepatitis C virus glycoproteins mediate viral infection in a CD81-dependent manner
We recently reported that retroviral pseudotypes bearing the hepatitis C virus (HCV) strain H
and Con1 glycoproteins, genotype 1a and 1b, respectively, require CD81 as a coreceptor for …
and Con1 glycoproteins, genotype 1a and 1b, respectively, require CD81 as a coreceptor for …
Identification of conserved residues in the E2 envelope glycoprotein of the hepatitis C virus that are critical for CD81 binding
Hepatitis C virus (HCV) cell entry involves interaction between the viral envelope
glycoprotein E2 and the cell surface receptor CD81. Knowledge of conserved E2 …
glycoprotein E2 and the cell surface receptor CD81. Knowledge of conserved E2 …
Structure-function analysis of hepatitis C virus envelope-CD81 binding
Hepatitis C virus (HCV) is a major human pathogen causing chronic liver disease. We have
recently found that the large extracellular loop (LEL) of human CD81 binds HCV. This …
recently found that the large extracellular loop (LEL) of human CD81 binds HCV. This …
Expression of human CD81 in transgenic mice does not confer susceptibility to hepatitis C virus infection
F Masciopinto, G Freer, VL Burgio, S Levy… - Virology, 2002 - Elsevier
We previously demonstrated that hepatitis C virus (HCV) binds to human CD81 through the
E2 glycoprotein. Therefore, expression of the human CD81 molecule in transgenic mice was …
E2 glycoprotein. Therefore, expression of the human CD81 molecule in transgenic mice was …
Novel function of CD81 in controlling hepatitis C virus replication
YY Zhang, BH Zhang, K Ishii, TJ Liang - Journal of virology, 2010 - Am Soc Microbiol
The mechanisms of hepatitis C virus (HCV) replication remain poorly understood, and the
cellular factors required for HCV replication are yet to be completely defined. CD81 is known …
cellular factors required for HCV replication are yet to be completely defined. CD81 is known …
[PDF][PDF] Prevention of hepatitis C virus infection and spread in human liver chimeric mice by an anti‐CD81 monoclonal antibody
C Ji, Y Liu, C Pamulapati, S Bohini, G Fertig… - …, 2015 - Wiley Online Library
CD81 is a required receptor for hepatitis C virus (HCV) infection of human hepatocytes in
vitro. We generated several high‐affinity anti‐human CD81 monoclonal antibodies (mAbs) …
vitro. We generated several high‐affinity anti‐human CD81 monoclonal antibodies (mAbs) …
CD81 is an entry coreceptor for hepatitis C virus
EG Cormier, F Tsamis, F Kajumo… - Proceedings of the …, 2004 - National Acad Sciences
Hepatitis C virus (HCV) envelope glycoproteins E1/E2 can pseudotype retroviral particles
and efficiently mediate entry into target cells. Using this experimental system, we determined …
and efficiently mediate entry into target cells. Using this experimental system, we determined …