Objective: Myocardial fibrosis is an important determinant of pathological hypertrophy. In two
experimental models of arterial hypertension the purpose of the study was (a) to determine …

Myocardial fibrosis resulting from arterial hypertension alters myocardial structure and
function. Myocardial fibrosis is characterized by a pathological accumulation of types I and III …

Activation of the renin-angiotensin-aldosterone system in arterial hypertension can lead to
remodeling of the myocardial collagen network, with progressive collagen accumulation in …

Cardiac fibrosis is one of the deleterious events accompanying hypertension that may be
implicated in the progression toward heart failure. To determine the mechanisms involved in …

Objective: Increased cardiac collagen is seen in uninephrectomised rats made hypertensive
by aldosterone infusion and high salt, with the possibility of a direct effect of aldosterone at …

Progressive myocardial fibrosis, including the accumulation of collagen within the adventitia
of intramyocardial coronary arteries, is seen in the hypertrophied rat myocardium secondary …

P. Lijnen and V. Petrov. Induction of Cardiac Fibrosis by Aldosterone. Journal of Molecular
and Cellular Cardiology (2000) 32, 865–879. An intracardiac aldosterone system which …

An alteration in the rate of collagen synthesis was observed in spontaneously hypertensive
rats during evolution of hypertension. An increase in rate of synthesis of collagen and a …

An abnormal elevation in collagen concentration or myocardial fibrosis occurs in the
hypertrophied left ventricle of the rat with renovascular hypertension (RHT). The structural …

Objective: In left ventricular hypertrophy (LVH) due to systemic hypertension, myocardial
fibrosis is an important determinant of pathologic hypertrophy. Therefore, it is most relevant …