Novel agents for multiple myeloma to overcome resistance in phase III clinical trials

RZ Orlowski - Seminars in oncology, 2013 - Elsevier
The incorporation of novel agents such as bortezomib and lenalidomide into initial therapy
for multiple myeloma has improved the response rate of induction regimens. Also, these …

Novel drug combinations for the management of relapsed/refractory multiple myeloma

SZ Usmani, S Lonial - Clinical Lymphoma Myeloma and Leukemia, 2014 - Elsevier
The outcomes and management of multiple myeloma (MM) in the United States have
changed dramatically over the past 15 years with the approval by the US Food and Drug …

Current standards for first-line therapy of multiple myeloma

S Jagannath - Clinical Lymphoma and Myeloma, 2007 - Elsevier
Current standards of care for first-line treatment of multiple myeloma are evolving rapidly
because of the introduction of regimens based on novel agents with unique mechanisms of …

Current treatment landscape for relapsed and/or refractory multiple myeloma

MA Dimopoulos, PG Richardson, P Moreau… - Nature reviews Clinical …, 2015 - nature.com
Recent developments in the treatment of multiple myeloma have led to improvements in
response rates and to increased survival; however, relapse is inevitable in almost all …

Management of relapsed and relapsed/refractory multiple myeloma

JP Laubach, CS Mitsiades, A Mahindra… - Journal of the National …, 2011 - jnccn.org
Despite significant progress in the treatment of multiple myeloma (MM) over the past
decade, this disease remains incurable and almost all patients ultimately experience …

Relapsed/refractory multiple myeloma: defining refractory disease and identifying strategies to overcome resistance

DS Siegel - Seminars in hematology, 2012 - Elsevier
Despite the development of more effective therapies for multiple myeloma (MM) over the
past decade, nearly all patients will eventually experience disease relapse and require …

Initial treatment of transplant-ineligible patients in multiple myeloma

MV Mateos, X Leleu, A Palumbo… - Expert review of …, 2014 - Taylor & Francis
Over two-thirds of newly diagnosed multiple myeloma are over 65 years. The treatment
goals for the non-transplant-eligible patients should be to prolong survival by achieving the …

Treatment of relapsed and refractory multiple myeloma in the era of novel agents

NWCJ van de Donk, HM Lokhorst, M Dimopoulos… - Cancer treatment …, 2011 - Elsevier
The introduction of the Immunomodulatory drugs (IMiDs) and proteasome inhibitors, used
either as a single-agent or combined with classic anti-myeloma therapies, has improved the …

Progress and paradigms in multiple myeloma

KC Anderson - Clinical Cancer Research, 2016 - AACR
Remarkable progress has been achieved in multiple myeloma, and patient median survival
has been extended 3-to 4-fold. Specifically, there have been 18 newly approved treatments …

Gaps and opportunities in the treatment of relapsed-refractory multiple myeloma: Consensus recommendations of the NCI Multiple Myeloma Steering Committee

S Kumar, L Baizer, NS Callander, SA Giralt… - Blood cancer …, 2022 - nature.com
A wide variety of new therapeutic options for Multiple Myeloma (MM) have recently become
available, extending progression-free and overall survival for patients in meaningful ways …