Following CNS injury, in an apparently counterintuitive response, scar tissue formation
inhibits axonal growth, imposing a major barrier to regeneration. Accordingly, scar …

Axonal regeneration and functional recovery are poor after spinal cord injury (SCI), typified
by the formation of an injury scar. While this scar was traditionally believed to be primarily …

The inflammatory response in the injured spinal cord, an immune privileged site, has been
mainly associated with the poor prognosis. However, recent data demonstrated that, in fact …

Spinal cord injury (SCI) is a complex tissue injury resulting in permanent and degenerating
damage to the central nervous system (CNS). Detrimental cellular processes occur after SCI …

Deficits in neuronal function are a hallmark of spinal cord injury (SCI) and therapeutic efforts
are often focused on central nervous system (CNS) axon regeneration. However, secondary …

Inadequate axonal regeneration is a common phenomenon occurring following acute injury
to the central nervous system (CNS), and is often associated with permanent neurological …

Traumatic spinal cord injury results in severe and irreversible loss of function. The injury
triggers a complex cascade of inflammatory and pathological processes, culminating in …

Glial scarring following severe tissue damage and inflammation after spinal cord injury (SCI)
is due to an extreme, uncontrolled form of reactive astrogliosis that typically occurs around …

Scar formation represents a reaction of nervous tissue to any form of physical injury.
Research over the past decade has demonstrated that the scar composed of glial cells and …

Severe spinal cord injury causes permanent loss of function and sensation throughout the
body. The trauma causes a multifaceted torrent of pathophysiological processes which …