Abstract Phosphoinositide 3-kinase (PI3K) pathway exerts its effects through Akt, its
downstream target molecule, and thereby regulates various cell functions including cell …

PI3K pathway exerts its function through its downstream molecule AKT in regulating various
cell functions including cell proliferation, cell transformation, cell apoptosis, tumor growth …

Prostate cancer presents with a broad spectrum of biologic behavior, ranging from being an
indolent, incidental finding to an aggressively invasive and metastatic disease. An improved …

The main mode of progression of ovarian cancer is peritoneal dissemination, and its
inhibition may lead to improved outcome. Phosphatase and tensin homologue deleted on …

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a cancer
suppressor gene and an important negative regulator in the phosphatidylinositide 3‑kinase …

BACKGROUND: Type-1 insulin-like growth factor (IGF-1) up-regulates cell proliferation and
invasiveness through activation of PI3K/Akt signaling pathway. IGF-1 also down-regulates …

Background Abnormality of PTEN gene and Wnt/β-catenin signaling have been strongly
implicated in various malignant cancers. Recently, it has been noted that a functional …

Hepatocellular carcinoma (HCC) is a typical hypervascular tumor, and increased levels of
vascular endothelial growth factor (VEGF) are associated with progression of HCC. Tumor …

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Most
patients with HCC die within one year after diagnosis largely because of frequent tumor …

Recent studies demonstrate that PI3K activation and PTEN mutation are frequently found in
many human cancer cells and tissues. However, the mechanism of PI3K signaling in human …