Endothelial cells control vascular tone by releasing nitric oxide (NO) produced by
endothelial NO synthase. The activity of endothelial NO synthase is modulated by the …

There are few discoveries with the magnitude of the impact that NO has had on biology
during the 25 years since its discovery. There is hardly a disease today not associated with …

Since its discovery, endothelium-derived nitric oxide (NO) has become one of the most
intensely investigated molecules in the field of cardiovascular physiology. Although initial …

The endothelium can evoke relaxations (dilatations) of the underlying vascular smooth
muscle, by releasing vasodilator substances. The best characterized endothelium-derived …

The vascular endothelium synthesises the vasodilator and anti-aggregatory mediator nitric
oxide (NO) from L-arginine. This action is catalysed by the action of NO synthases, of which …

Endothelium-derived nitric oxide (NO) is a key determinant of blood pressure homeostasis
and platelet aggregation and is synthesized by the endothelial isoform of nitric oxide …

As the first discovered gaseous signaling molecule, nitric oxide (NO) affects a number of
cellular processes, including those involving vascular cells. This brief review summarizes …

▪ Abstract Endothelial nitric oxide synthase (eNOS) is expressed in vascular endothelium,
airway epithelium, and certain other cell types where it generates the key signaling molecule …

Among all physiologic functions of nitric oxide (NO) known so far, NO-dependent regulation
of vascular tone is one of the most important. Under physiological conditions vascular NO is …

The endothelium synthesizes and releases nitric oxide (NO) to maintain homeostatic
function. Under basal conditions, endothelium-derived NO maintains a nonthrombogenic …