▪ Abstract Nitric oxide (NO) is a small, diffusible, lipophilic free radical gas that mediates
significant and diverse signaling functions in nearly every organ system in the body. The …

The vascular endothelium plays a crucial role in the regulation of vascular homeostasis and
in preventing the initiation and progress of cardiovascular disease by controlling mechanical …

Endothelial nitric oxide synthase (eNOS) is important for cardiovascular homeostasis, vessel
remodeling, and angiogenesis. Given the impact of endothelium-derived nitric oxide (NO) in …

▪ Abstract The product of nitric oxide (NO) synthase is the most potent endogenous
vasodilator known. NO not only is a potent vasodilator, it also inhibits platelet adherence and …

The endothelium is a single cell layer that lines all blood vessels. This tissue produces an
impressive array of paracrine factors that maintain vascular homeostasis. One of these …

Since the discovery of endothelium-derived relaxing factor and the subsequent identification
of nitric oxide (NO) as the primary mediator of endothelium-dependent relaxations, research …

In the past decade, the importance of the vascular endothelium as a multifunctional regulator
of vascular smooth muscle physiology and pathophysiology has been appreciated. Indeed …

NO, constitutively produced by endothelial NO synthase (eNOS), plays a key regulatory role
in vascular wall homeostasis. We generated transgenic (Tg) mice overexpressing eNOS in …

Nitric oxide (NO) produced in the endothelium via the enzyme endothelial nitric-oxide
synthase (eNOS) is an important vasoactive compound. Wild-type (WT) eNOS is localized to …

In retrospect, basic research in the fields of nitric oxide (NO) and cyclic guanosine
monophosphate (cGMP) during the past two decades appears to have followed a logical …