Endothelial dysfunction is an independent predictor of cardiovascular risk. It is found with
aging, and in many conditions associated with increased cardiovascular risk such as …

Angiogenesis requires the elaboration of endothelium-derived nitric oxide (NO). Angiogenic
factors induce the release of NO from endothelial cells, which mediates a multiplicity of …

The field of nitric oxide (NO) research has developed in explosive proportions since the
discovery of endogenous NO in 1986. The biological importance of NO was first shown by …

Several lines of evidence indicate that nitric oxide (NO) impairs endothelin (ET)
production/action in vitro. Acute pressor responses caused by the blockade of NO formation …

In contrast with the short research history of the enzymatic synthesis of nitric oxide (NO), the
introduction of nitrate‐containing compounds for medicinal purposes marked its 150th …

The vascular endothelium mediates the ability of blood vessels to alter their architecture in
response to hemodynamic changes; however, the specific endothelial-derived factors that …

The endothelium lines the luminal surface of every blood vessel, allowing it contact with
circulating blood elements, as well as the underlying vascular smooth muscle layer. In …

Nitric oxide produced by three different isoforms of nitric oxide synthase (NOS) widely
expressed in virtually all vascular cell types is mostly produced by the endothelial isoform …

A hallmark of inflammation is increased vascular permeability. Increases in vascular
permeability and the migration of inflammatory cells are linked to complex interactions of …

Endothelium-dependent relaxations mediated by nitric oxide (NO) are attenuated in arteries
exposed to proinflammatory mediators. Because proinflammatory mediators stimulate the …