The concept of endothelium‐derived relaxing factor (EDRF) put forward in 1980 by Furchgott
and Zawadzki implies that nitric oxide (NO) produced by NO synthase (NOS) in the …

Nitric oxide (NO), the smallest signalling molecule known, is produced by three isoforms of
NO synthase (NOS; EC 1.14. 13.39). They all utilize l-arginine and molecular oxygen as …

The different cell types comprising cardiac muscle express one or more of the three isoforms
(neuronal NOS, or nNOS; inducible NOS, or iNOS; and endothelial NOS, or eNOS) of nitric …

Consistent with its classification as a Ca2+/calmodulin-dependent enzyme the constitutive
endothelial nitric oxide (NO) synthase (eNOS) can be activated by receptor-dependent and …

A hallmark of inflammation is increased vascular permeability. Increases in vascular
permeability and the migration of inflammatory cells are linked to complex interactions of …

In normal vascular physiology, NO plays a key role to maintain the vascular wall in a
quiescent state by inhibition of inflammation, cellular proliferation, and thrombosis. This is in …

Nitric oxide (NO) is an important molecular messenger accounting for endothelium-derived
relaxing factor. Recently, NO synthase (NOS) from cultured endothelial cells has been …

Nitric oxide (NO) and endothelin-1 (ET-1) are natural counterparts in vascular function, and it
is becoming increasingly clear that an imbalance between these two mediators is a …

The vascular endothelium synthesizes and releases a spectrum of vasoactive substances
like nitric oxide (NO) and endothelin (ET). In hypertension, the delicate balance of …

Endothelium derived nitric oxide (NO) plays a major role in cardiovascular homeostasis. It
has important antiatherosclerotic properties which include regulation of vasomotor tone and …