To characterize the mechanisms underlying region-and age-dependent hippocampal
synaptic dysfunction in Alzheimer's disease, we used transgenic CRND8 mice, expressing …

The present study reports changes in synaptic function and plasticity [long-term potentiation
(LTP)] in a recently developed mouse model of Alzheimer's disease (CRND8 line) harboring …

The synaptic changes underlying the onset of cognitive impairment in Alzheimer's disease
(AD) are poorly understood. In contrast to the well documented inhibition of long-term …

It is widely thought that Alzheimer's disease (AD) begins as a malfunction of synapses,
eventually leading to cognitive impairment and dementia. Homeostatic synaptic scaling is a …

APP. V717I and Tau. P301L transgenic mice develop Alzheimer's disease pathology
comprising important aspects of human disease including increased levels of amyloid …

BACKGROUND: The aim of this study was to determine whether neocortical long-term
potentiation (LTP) is deficient in patients with Alzheimer's disease (AD) and in amyloid …

Many endogenous factors influence the time course and extent of the detrimental effects of
amyloid β-protein (Aβ) on synaptic function. Here, we assessed the impact of varying …

Aging is associated with a decline in cognitive function which could be due to reduced
synaptic plasticity. Hippocampal long-term potentiation (LTP) is an activity-dependent form …

Background Alzheimer disease (AD) is a neurodegenerative disorder for which there is no
cure. We have investigated synaptic plasticity in area CA1 in a novel AD mouse model …

Abnormal processing of amyloid precursor protein (APP), in particular the generation of β-
amyloid (Aβ) peptides, has been implicated in the pathogenesis of Alzheimer's disease. This …