Enhanced inflammatory transcriptome in the granulosa cells of women with polycystic ovarian syndrome

J Adams, Z Liu, YA Ren, WS Wun… - The Journal of …, 2016 - academic.oup.com
Context: Polycystic ovarian syndrome (PCOS), the most common endocrine disorder of
reproductive-aged women, is associated with systemic low-grade inflammation. Objective …

Altered gene expression profile in cumulus cells of mature MII oocytes from patients with polycystic ovary syndrome

D Haouzi, S Assou, C Monzo, C Vincens… - Human …, 2012 - academic.oup.com
STUDY QUESTION Oocyte developmental competence is altered in patients with polycystic
ovary syndrome (PCOS); is gene expression in cumulus cells (CCs) from mature metaphase …

[HTML][HTML] Effects of androgen excess-related metabolic disturbances on granulosa cell function and follicular development

B Liao, X Qi, C Yun, J Qiao, Y Pang - Frontiers in endocrinology, 2022 - frontiersin.org
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease in women
of reproductive age. Ovarian dysfunction including abnormal steroid hormone synthesis and …

Effect of nutritional supplementation on oxidative stress and hormonal and lipid profiles in PCOS-affected females

P Dubey, S Reddy, S Boyd, C Bracamontes, S Sanchez… - Nutrients, 2021 - mdpi.com
Polycystic ovary syndrome (PCOS) affects several reproductive and endocrine features in
females and has a poorly understood etiology. Treatment strategies for PCOS are limited …

Updates in diagnosing polycystic ovary syndrome-related infertility

H Haddad-Filho, JAG Tosatti, FM Vale… - Expert Review of …, 2023 - Taylor & Francis
Introduction Polycystic ovary syndrome (PCOS) is a condition that affects approximately 13%
of reproductive age women and is characterized by androgen excess, menstrual irregularity …

Granulosa cell survival and proliferation are altered in polycystic ovary syndrome

M Das, O Djahanbakhch… - The Journal of …, 2008 - academic.oup.com
Context: Polycystic ovary syndrome (PCOS) represents the most common endocrine
abnormality in women of reproductive age. The cause of PCOS remains largely unknown …

[HTML][HTML] Altered circulating inflammatory cytokines are associated with anovulatory polycystic ovary syndrome (PCOS) women resistant to clomiphene citrate treatment

LL Wang, HB Qi, PN Baker, QN Zhen… - … medical journal of …, 2017 - ncbi.nlm.nih.gov
Background Polycystic ovary syndrome (PCOS) is a common gynecological disease
characterized by chronic oligoanovulation, clinical/biochemical hyperandrogenism …

In search of new therapeutics—molecular aspects of the PCOS pathophysiology: genetics, hormones, metabolism and beyond

A Wawrzkiewicz-Jałowiecka, K Kowalczyk… - International Journal of …, 2020 - mdpi.com
In a healthy female reproductive system, a subtle hormonal and metabolic dance leads to
repetitive cyclic changes in the ovaries and uterus, which make an effective ovulation and …

Metabolism alteration in follicular niche: The nexus among intermediary metabolism, mitochondrial function, and classic polycystic ovary syndrome

H Zhao, Y Zhao, T Li, M Li, J Li, R Li, P Liu, Y Yu… - Free Radical Biology …, 2015 - Elsevier
Classic polycystic ovary syndrome (PCOS) is a high-risk phenotype accompanied by
increased risks of reproductive and metabolic abnormalities; however, the local metabolism …

Evidence from animal models on the pathogenesis of PCOS

KA Walters, MJ Bertoldo, DJ Handelsman - Best Practice & Research …, 2018 - Elsevier
Polycystic ovarian syndrome (PCOS) is the most common endocrine condition in women,
and is characterized by reproductive, endocrine and metabolic features. However, there is …