Significance: Cytokines released in and around pancreatic islets during islet inflammation
are believed to contribute to impaired β cell function and β cell death during the …

Autoimmune diabetes is characterized by the selective destruction of insulin-secreting β-
cells that occurs during an inflammatory reaction in and around pancreatic islets of …

Nitric oxide, produced in pancreatic β cells in response to proinflammatory cytokines, plays a
dual role in the regulation of β-cell fate. While nitric oxide induces cellular damage and …

The radical nitric oxide (NO) may be a mediator of pancreatic beta-cell damage in early
insulin-dependent diabetes mellitus (IDDM). Under the stimulus of cytokines, invading …

Insulin, produced by pancreatic β-cells, is responsible for the control of whole-body glucose
metabolism. Insulin is secreted by pancreatic β-cells in a tightly regulated process that is …

In pancreatic islets, nitric oxide (NO) produced on exposure to cytokines mediates β-cell
injury leading to diabetes mellitus. On the other hand, l-arginine-derived NO may participate …

While exposure to inflammatory cytokines is thought to contribute to pancreatic β-cell
damage during diabetes, primarily because cytokine-induced nitric oxide impairs β-cell …

Nitric oxide is thought to contribute to beta cell destruction during islet inflammation in
animal models of type I diabetes. In vitro, inhibition of inducible nitric oxide synthase protects …

Although nitric oxide (NO) and oxidative stress both contribute to proinflammatory cytokine
toxicity in pancreatic β-cells during type 1 diabetes mellitus (T1DM) development, the …

Reactive oxygen species (ROS) and nitric oxide (NO) are proposed mediators of cytokine-
induced β-cell destruction in type 1 diabetes. We produced transgenic mice with increased β …