Ventilatory instability may play an important role in the pathogenesis of obstructive sleep
apnea. We hypothesized that the influence of ventilatory instability in this disorder would …

Abstract Study Objectives: Certain respiratory control characteristics determine whether
patients with collapsible upper airway develop stable or unstable breathing during sleep …

Considerable progress has been made over the last several decades in our understanding
of the pathophysiology of both central and obstructive sleep apnea. Central sleep apnea, in …

Changes in sleep posture have been shown to improve obstructive sleep apnea (OSA). To
investigate the mechanisms by which this occurs we assessed upper airway stability in eight …

We compared the effect of oxygen on the apnea–hypopnea index (AHI) in six obstructive
sleep apnea patients with a relatively high loop gain (LG) and six with a low LG. LG is a …

Rationale: There is increasing evidence of increased ventilatory instability in patients with
obstructive sleep apnea (OSA), but previous investigations have not studied whether the …

Obstructive sleep apnea (OSA) is two to three times more common in men as in women. The
mechanisms leading to this difference are currently unclear but could include gender …

The response to chemical stimuli (chemical responsiveness) and the increases in
respiratory drive required for arousal (arousal threshold) and for opening the airway without …

Because of the oscillatory pattern of upper airway resistance and breathing during sleep in
patients with obstructive sleep apnea (OSA), we hypothesized that OSA patients have an …

Previous studies have demonstrated that lung volume during wakefulness influences upper
airway size and resistance, particularly in patients with sleep apnea. We sought to determine …