Purpose: The availability of various transgenic and knockout mice provides an excellent
opportunity to better understand the pathophysiology of calcium oxalate stone disease …

Calcium oxalate stone disease is the most common human urinary stone disease in the
Western Hemisphere. To understand different aspects of the disease, calcium oxalate …

Calcium oxalate (CaOx) urolithiasis in rats is induced by producing hyperoxaluria.
Depending on the degree and length of hyperoxaluria, CaOx crystals may either form in the …

To better understand the pathogenesis of nephrolithiasis, we developed a new animal
model that closely mimics human calcium oxalate stone disease. Rats were treated with a …

PURPOSE: Patients with calcium oxalate kidney stones are advised to decrease the
consumption of foods that contain oxalate. We hypothesized that a cutback in dietary oxalate …

Background: Although nephrotoxic in high doses, ethylene glycol (EG) has been used with
ammonium chloride (NH4Cl) or vitamin D3 to study calcium oxalate stone formation in rat …

Crystallization of salts in the urine is a process common to many mammals including
humans. The crystals are either harmlessly excreted as crystalluria particles or are retained …

Calcium oxalate stone formation in genetic hypercalciuric stone-forming rats. Background
Over 54 generations, we have successfully bred a strain of rats that maximizes urinary …

Urinary calcium oxalate (CaOx) crystals and crystal agglomerates are normally harmlessly
excreted, but in nephrolithiasis they are retained by tubular epithelial cells and shifted into …

In human nephrolithiasis, most stones are containing calcium and are located within urinary
cavities; they may contain monohydrate calcium oxalate, dihydrate calcium oxalate and/or …