The unique polarization and high‐energy demand of neurons necessitates specialized
mechanisms to maintain energy homeostasis throughout the cell, particularly in the distal …

Mitochondria are key cellular power plants essential for neuronal growth, survival, function,
and regeneration after injury. Given their unique morphological features, neurons face …

Mitochondria generate ATP essential for neuronal growth, function, and regeneration. Due
to their polarized structures, neurons face exceptional challenges to deliver mitochondria to …

Human studies consistently identify bioenergetic maladaptations in brains upon aging and
neurodegenerative disorders of aging (NDAs), such as Alzheimer's disease, Parkinson's …

Highlights•Myelin is an insulator that can shield long axons from rapid access to
metabolites.•Oligodendrocytes can 'feed'axons with glycolysis products such as …

The unique morphology and functionality of central nervous system (CNS) neurons
necessitate specialized mechanisms to maintain energy metabolism throughout long axons …

Although neuronal regeneration is a highly energy-demanding process, axonal
mitochondrial transport progressively declines with maturation. Mature neurons typically fail …

Oligodendrocytes are best known for wrapping myelin, a unique specialization that enables
energy-efficient and fast axonal impulse propagation in white matter tracts and fibers of the …

Over the last decade, mitochondrial dynamics beyond function during axon regeneration/
degeneration have received attention. Axons have an effective delivery system of …

Axon regeneration is essential to restore the nervous system after axon injury. However, the
neuronal cell biology that underlies axon regeneration is incompletely understood. Here we …