Objectives Patients with heartburn and normal upper gastrointestinal endoscopy, normal
oesophageal acid exposure, no symptom-reflux association and who fail to respond to a …

Methods Fifty proton pump inhibitotor refractory patients (11 male, 48 years [range, 38–57
years]) with a diagnosis of functional heart-burn according to Rome III in the first 24 hours of …

Background Patients with functional heartburn (FH) experience troublesome heartburn that
is not related to gastroesophageal reflux. The etiology of the heartburn sensation in FH …

METHODS: A total of 111 patients with proton pump inhibitor (PPI)-refractory non-erosive
gastroesophageal reflux disease underwent intraesophageal pressure testing and 24-h …

INTRODUCTION: Functional heartburn is defined by Rome III criteria as an endoscopy-
negative condition with normal oesophageal acid exposure time, negative symptom …

Functional heartburn: An underrecognized cause of PPI-refractory symptoms Page 1 Functional
heartburn: An underrecognized cause of PPI-refractory symptoms CLEVELAND CLINIC …

Background Hypersensitive esophagus (HE) is defined by endoscopy-negative heartburn
with a normal acid exposure time but positive symptom association probability (SAP) and/or …

Background By analysis of symptom‐reflux association, endoscopy‐negative refractory
heartburn can be related to acid/non‐acid refluxes with impedance‐pH monitoring …

Functional heartburn (FH) is defined as a functional esophageal disorder characterized by
symptoms of chronic heartburn with no apparent correlation to acid or nonacid reflux. In …

Heartburn is among the most common gastrointestinal symptoms presenting to both
generalist physicians and gastroenterologists. Heartburn that does not respond to traditional …