Non-erosive reflux disease (NERD) and functional heartburn (FH) are two different clinical
entities and the clear distinction between the two forms is actually possible thanks to the use …

Objective. A pooled analysis, using data from three prospective, randomized, double-blind,
placebo-controlled, clinical studies, was undertaken to determine the relationship between …

Objective. To investigate the differences in the results of esophageal function tests for
functional heartburn (FH) and reflux hypersensitivity (RH). Methods. Patients with FH and …

Multichannel impedance pH monitoring has shown that weakly acidic refluxes are able to
generate heartburn. However, data on the role of different pH values, ranging between 4 …

Abstract Background and Aim There are heterogeneous subgroups among those with
heartburn, and data on these individuals are relatively scant. We aimed to evaluate the effect …

Background Proton pump inhibitor (PPI)‐refractory heartburn may be due to persistent
gastro‐oesophageal reflux, oesophageal hypersensitivity or functional heartburn (FH). The …

Background The phenotypes of heartburn patients are heterogeneous. Objective The
objective of this study was to investigate the proportion of heartburn phenotypes in a …

Abstract Background and Aim: Studies have shown that altered visceral perception and
lower pain thresholds in patients with symptomatic gastroesophageal reflux disease (GERD) …

Best Practice Advice 1 A diagnosis of functional heartburn should be considered when
retrosternal burning pain or discomfort persists despite maximal (double-dose) proton pump …

Methods Patients with heartburn underwent endoscopy and pH testing and were stratified
into 3 groups: erosive esophagitis (EE), nonerosive reflux disease (NERD), and functional …