Background Patients with heartburn but without esophageal erosion respond less well to
proton pump inhibitors (PPI s). There is a growing body of evidence implicating the role of …

Patients with refractory heartburn to proton pump inhibitors (PPIs) represent a distinctive
group which is difficult to manage. In a systematic review of the relative literature we found …

Aims To assess the contribution of 24-h esophageal multichannel intraluminal impedance
and pH (MII-pH) monitoring and high resolution endoscopy (HRE) with i-scan imaging in …

Introduction Symptom association is important to distinguish non-erosive reflux disease
[NERD; abnormal oesophageal acid exposure time (AET) and/or positive symptom …

Several studies have indicated an overlap between gastroesophageal reflux disease
(GERD) and various functional gastrointestinal disorders (FGIDs). The overlapping …

Background Twenty per cent of patients with heartburn do not respond to proton pump
inhibitors (PPIs). Many have normal oesophageal acid exposure. We hypothesized that such …

Background Symptom association probability (SAP) is thought to distinguish reflux
hypersensitivity from functional disorders. A diagnosis of hypersensitive oesophagus (SAP …

Background Acid exposure time (AET) is considered the most useful parameter to predict
response of reflux‐related heartburn to medical or surgical treatment. However, recent …

OBJECTIVE: Little is known about esophageal nociceptive thresholds in chronic heartburn
sufferers with normal clinical findings. The aim of this study was to evaluate and to …

Background Mucosal innervation in non‐erosive reflux disease (NERD; pathological
esophageal acid exposure, normal macroscopic mucosa) is clearly distinct from that of …