Given the limited efficacy of available pharmacotherapies for treatment of alcohol use
disorder (AUD), the need for new medications is substantial. Preclinical studies have shown …

Alcohol use disorder (AUD) is a chronic relapsing condition characterized by compulsive
alcohol-seeking behaviors, with serious detrimental health consequences. Despite high …

Although the multifaceted mechanisms underlying alcohol use disorder (AUD) have been
partially defined, the neurobiological complexity of this disorder is yet to be unraveled. One …

The neurochemical mechanisms that regulate development of alcohol use disorder (AUD)
are complex, and gut-brain peptides were recently pinpointed as novel modulators. Gut …

BACKGROUND Alcohol use disorder has a detrimental impact on global health and new
treatment targets are needed. Preclinical studies show attenuating effects of glucagon-like …

BACKGROUND: Growing evidence supports a role of metabotropic glutamate receptors
(mGluRs) in ethanol reinforcement, ethanol seeking, and ethanol withdrawal. To extend the …

Background Preclinical studies in rodents have demonstrated inhibitory effects of glucagon-
like peptide-1 (GLP-1) receptor stimulation on alcohol consumption. The effects of GLP-1 …

Rationale Alcohol use disorder remains a leading cause of preventable deaths, and current
treatments have limited efficacy. Glucagon-like peptide 1 (GLP-1) receptor agonists can …

Growing evidence suggests that the glucagon‐like peptide‐1 (GLP‐1) system modulates
alcohol seeking and consumption, and GLP‐1 analogues may represent novel …

Alcohol addiction, affecting approximately four percent of the population, contributes
significantly to the global burden of diseases and is a substantial cost to the society. The …