The migration of lymphocytes through primary cultures of rat brain microvascular endothelial
cell monolayers was examined in vitro by time-lapse videomicroscopy. Antigen-specific T …

Lymphocyte adhesion to and migration across endothelial cell (EC) monolayers, derived
from the rat blood-retinal barrier (BRB), were measured in vitro. The binding of concanavalin …

Increased lymphocyte traffic across an altered blood-brain barrier (BBB) is a prominent and
early event in inflammatory and immune-mediated CNS diseases. The factors that control …

Migration of leukocytes through an in vitro, cell culture model of the blood-brain barrier
(BBB) composed of murine brain microvessel endothelial (En) cells and astrocytes, and in …

We report on a series of experiments which examines the factors controlling lymphocyte
adhesion to brain endothelium in vitro and the factors which control cell migration across the …

We describe a recently developed assay for the analysis of leukocyte migration across
cerebral endothelium in vitro. The endothelium is grown as monolayers on Goretex or …

We examined the changes in intercellular adhesion molecule-1 (ICAM-1) expression on
brain endothelium in response to tumour necrosis factor-alpha (TNF-alpha) and interferon …

Factors controlling lymphocyte adhesion to brain endothelium were investigated in vitro.
Mitogen activation of lymphocytes causes increased adhesion to endothelium, which is …

We have used human brain-derived endothelial cells (HBECs) maintained under basal
culture conditions in a Boyden chamber assay system as an in vitro model of migration of …

Endothelial cells of the blood-brain barrier (BBB) have the ability to regulate and restrict the
passage of cells and molecules from the periphery to the CNS. We have used an in vitro …