The authors established a highly sensitive, specific and quantitative method-RT-PCR for
measuring the levels of MDR1 mRNA in 91 acute leukemic samples (including 30 untreated …

The method of reverse transcription coupled with polymerase chain reaction (RT-PCR) has
been used to detect multidrug resistance gene MDR1 expression in 73 leukemia patients …

Methods The expression of multidrug resistance gene (mdr1) mRNA was measured in 85
patients with acute leukemia and in 20 normal controls by using reverse transcription …

Acute myeloid leukemia (AML) has a poor long-term prognosis, with a disease-free survival
rate of only 20%. Drug resistance remains the major obstacle in this disease, although …

One important mechanism of drug resistance in acute leukemia is the overexpression of the
multi-drug resistance (MDR1) gene that encodes a 170-kDa membrane protein called P …

BACKGROUND: The expression of the multidrug resistance-1 (MDR-1) gene which encodes
p-glycoprotein, is recognized as a biological mechanism possibly contributing to treatment …

OBJECTIVE: Multidrug resistance (MDR) is one of the most important reasons for treatment
failure and recurrence of acute leukemia. Its manifestations are different in children with …

RT-PCR method was used to detect the expression level of multi-drug resistance gene
(MDR1) and multi-drug resistance associated protein (MRP) in patients with malignant blood …

The prognostic significance of multidrug resistance (MDR) gene expression is controversial.
We investigated whether multidrug resistance gene 1 (MDR1), multidrug resistance-related …

To evaluate the frequency and the prognostic value of different mechanisms of drug
resistance in acute leukemias, we investigated the expression of mdr 1 by …