Agouti-related peptide (AgRP) neurons of the hypothalamus play a key role in regulating
food intake and body weight, by releasing three different orexigenic molecules: AgRP; …

Maintaining energy homeostasis requires coordinating physiology and behavior both on an
acute timescale to adapt to rapid fluctuations in caloric intake and on a chronic timescale to …

Agouti-related peptide (AgRP) neurons of the hypothalamus release a fast transmitter
(GABA) in addition to neuropeptides (neuropeptide Y [NPY] and Agouti-related peptide …

The current obesity epidemic and lack of efficient therapeutics demand a clear
understanding of the mechanism underlying body weight regulation. Despite intensive …

The obesity epidemic is a major health and economic burden facing both developed and
developing countries worldwide. Interrogation of the central and peripheral mechanisms …

Agouti-related peptide (AgRP) neurons of the arcuate nucleus of the hypothalamus (ARC)
promote homeostatic feeding at times of caloric insufficiency, yet they are rapidly …

Feeding behavior is exquisitely regulated by homeostatic and hedonic neural substrates that
integrate energy demand as well as the reinforcing and rewarding aspects of food …

The current obesity epidemic is a major worldwide health and economic burden. In the
modern environment, an increase in the intake of high-fat and high-sugar foods plays a …

Hypothalamic agouti-related peptide (AgRP) neurons potently stimulate food intake,
whereas proopiomelanocortin (POMC) neurons inhibit feeding. Whether AgRP neurons …

The physiologic importance of GABAergic neurotransmission in hypothalamic neurocircuits
is unknown. To examine the importance of GABA release from agouti-related protein (AgRP) …