Expanding roles of de novo lipogenesis in breast cancer

P Simeone, S Tacconi, S Longo, P Lanuti… - International journal of …, 2021 - mdpi.com
In recent years, lipid metabolism has gained greater attention in several diseases including
cancer. Dysregulation of fatty acid metabolism is a key component in breast cancer …

[HTML][HTML] Fatty acid metabolism in breast cancer subtypes

ME Monaco - Oncotarget, 2017 - ncbi.nlm.nih.gov
Dysregulation of fatty acid metabolism is recognized as a component of malignant
transformation in many different cancers, including breast; yet the potential for targeting this …

Lipid biology of breast cancer

J Baumann, C Sevinsky, DS Conklin - … (BBA)-Molecular and Cell Biology of …, 2013 - Elsevier
Alterations in lipid metabolism have been reported in many types of cancer. Lipids have
been implicated in the regulation of proliferation, differentiation, apoptosis, inflammation …

Fatty acid and phospholipid biosynthetic pathways are regulated throughout mammary epithelial cell differentiation and correlate to breast cancer survival

ML Dória, AS Ribeiro, J Wang, CZ Cotrim… - The FASEB …, 2014 - Wiley Online Library
This work combined gene and protein expression, gas chromatography‐flame ionization
detector, and hydrophilic interaction liquid chromatography‐tandem mass spectrometry to …

Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression

M Hilvo, C Denkert, L Lehtinen, B Müller, S Brockmöller… - Cancer research, 2011 - AACR
Activation of lipid metabolism is an early event in carcinogenesis and a central hallmark of
many cancers. However, the precise molecular composition of lipids in tumors remains …

Regulation of lipid metabolism in breast cancer provides diagnostic and therapeutic opportunities

M Hilvo, A Matej Orešiè - Clinical Lipidology, 2012 - Taylor & Francis
During malignant transformation, the lipid metabolism of cells changes radically and
therefore alterations in lipid metabolism are a prominent feature of solid tumors. Lipid …

The impact of lipid metabolism on breast cancer: a review about its role in tumorigenesis and immune escape

D Zipinotti dos Santos, JC de Souza… - Cell Communication and …, 2023 - Springer
Background Breast cancer (BC) is the second most frequent type of cancer in the world and
most common among women, configuring a major challenge to global health. BC is a …

Docosahexaenoic acid modulates a HER2‐associated lipogenic phenotype, induces apoptosis, and increases trastuzumab action in HER2‐overexpressing breast …

GR Ravacci, MM Brentani, TC Tortelli… - BioMed research …, 2015 - Wiley Online Library
In breast cancer, lipid metabolic alterations have been recognized as potential oncogenic
stimuli that may promote malignancy. To investigate whether the oncogenic nature of …

Increased lipogenesis in cancer cells: new players, novel targets

JV Swinnen, K Brusselmans… - Current Opinion in …, 2006 - journals.lww.com
The same disturbances in signaling pathways responsible for oncogenic transformation may
also contribute to the increased lipogenesis observed in tumor cells. Increased lipogenesis …

Exogenous fatty acids modulate ER lipid composition and metabolism in breast cancer cells

AM Rizzo, I Colombo, G Montorfano, S Zava… - Cells, 2021 - mdpi.com
(1) Background: Lipid metabolism is a fundamental hallmark of all tumors, especially of
breast cancer. Few studies describe the different lipid metabolisms and sensitivities to the …