Valsartan in the treatment of hypertension

SE Kjeldsen, HR Brunner, GT McInnes, P Stolt - Aging Health, 2005 - Taylor & Francis
Valsartan is a widely used, efficacious and very well-tolerated antihypertensive agent. By
specifically blocking the action of angiotensin II on the angiotensin Type 1 receptor …

Valsartan: long term efficacy and tolerability compared to lisinopril in elderly patients with essential hypertension

B Ad, OS P - Clinical and Experimental Hypertension, 1997 - Taylor & Francis
A total of 501 elderly patients with essential hypertension were randomized to receive
valsartan or lisinopril in this one year multi-center, double-blind, parallel group trial. Patients …

Clinical advantage of valsartan

GT McInnes - Cardiology, 1999 - karger.com
Valsartan is a specific angiotensin II receptor antagonist with high selectivity for the AT 1
receptor subtype. After oral administration of single or repeated once-daily doses, valsartan …

Valsartan: a review of its pharmacology and therapeutic use in essential hypertension

A Markham, KL Goa - Drugs, 1997 - Springer
Synopsis Valsartan competitively and selectively inhibits the actions of angiotensin II at the
AT 1 receptor subtype which is responsible for most of the known effects of angiotensin II. In …

Valsartan: a novel angiotensin type 1 receptor antagonist

PA Thürmann - Expert Opinion on Pharmacotherapy, 2000 - Taylor & Francis
Valsartan is a highly selective, orally available antagonist of the angiotensin Type 1 (AT1)
receptor. It is indicated for treatment of mild to moderate essential hypertension …

The angiotensin receptor antagonist valsartan: a review of the literature with a focus on clinical trials

NB Mistry, AS Westheim… - Expert opinion on …, 2006 - Taylor & Francis
Valsartan is an angiotensin receptor antagonist that specifically blocks the angiotensin II
type 1 receptors. It is an effective and well-tolerated once-daily antihypertensive agent, with …

Pharmacology of valsartan, an angiotensin II receptor antagonist

A Chiolro, M Burnier - Expert opinion on investigational drugs, 1998 - Taylor & Francis
Valsartan is the second orally-active, non-peptide angiotensin II receptor blocker to reach
the market in Europe and the USA for the treatment of hypertension. Preclinical studies have …

Valsartan: more than a decade of experience

HR Black, J Bailey, D Zappe, R Samuel - Drugs, 2009 - Springer
Valsartan is a nonpeptide angiotensin receptor antagonist that selectively blocks the binding
of angiotensin II to the angiotensin II type 1 receptor. The efficacy, tolerability and safety of …

The valsartan antihypertensive long-term use evaluation (VALUE) trial: outcomes in patients receiving monotherapy

S Julius, MA Weber, SE Kjeldsen, GT McInnes… - …, 2006 - Am Heart Assoc
In the main Valsartan Antihypertensive Long-Term Use Evaluation (VALUE) report, we
investigated outcomes in 15 245 high-risk hypertensive subjects treated with valsartan-or …

Assessment of the optimal daily dose of valsartan in patients with hypertension, heart failure, or both

P Verdecchia, F Angeli - Clinical therapeutics, 2004 - Elsevier
Background: Recent data suggest that use of relatively high doses of angiotensin II-receptor
blockers (ARBs) in hypertensive patients at high cardiovascular risk may reduce the …