Towards second generation hypericin based photosensitizers for photodynamic therapy

M Waser, H Falk - Current Organic Chemistry, 2007 - ingentaconnect.com
Its outstanding ability to generate singlet oxygen or reactive oxygen species upon irradiation
with light makes hypericin one of the most powerful photosensitizers to be found in nature …

Progress in the chemistry of second generation hypericin based photosensitizers

M Waser, H Falk - Current Organic Chemistry, 2011 - ingentaconnect.com
Its outstanding ability to generate singlet oxygen or reactive oxygen species upon irradiation
with light makes hypericin one of the most powerful photosensitizers to be found in Nature …

In vitro study of the photocytotoxicity of bathochromically-shifted hypericin derivatives

M Roelants, B Lackner, M Waser, H Falk… - Photochemical & …, 2009 - Springer
Hypericin has excellent photosensitizing properties and displays favorable tumouritropic
characteristics, but at the same time exhibits minimal dark toxicity. As such, the compound is …

A route to amino functionalized hypericin derivatives and their chemical and photochemical properties pertaining to photodynamic therapy

B Lackner, K Bretterbauer, C Schwarzinger… - Monatshefte für Chemie …, 2005 - Springer
Syntheses of amino functionalized hypericin derivatives could be achieved starting from the
recently prepared emodin derived 1, 3, 8-trimethoxy-6-amino-9, 10-anthraquinone. Our …

Hypericin-a new antiviral and antitumor photosensitizer: mechanism of action and interaction with biological macromolecules

P Miskovsky - Current drug targets, 2002 - ingentaconnect.com
Hypericin, a naturally occurring pigment, is found in certain species of plants from the genus
Hypericum, the most common of which is Saint John's Wort (Hypericum perforatum). Recent …

Hypericin in photobiological assays: An overview

GP de Andrade, TFM de Souza, G Cerchiaro… - Photodiagnosis and …, 2021 - Elsevier
Hypericin is considered a potent photosensitizer for use in antitumor and antimicrobial
photodynamic therapy (PDT). This review presents the primary biological results obtained …

Cellular mechanisms and prospective applications of hypericin in photodynamic therapy

T Kiesslich, B Krammer… - Current medicinal …, 2006 - ingentaconnect.com
During the last decades, Photodynamic Therapy (PDT) has been established as a powerful
alternative approved by health agencies of several countries for treatment of various …

Synthesis and Properties of 10, 11-Dibenz-imidazolyl-10, 11-didesmethyl-hypericin–The First Heterocyclically Substituted Hypericin Derivative

B Lackner, C Etzlstorfer, H Falk - Monatshefte für Chemie/Chemical …, 2004 - Springer
The synthesis of the first heterocyclically substituted title hypericin derivative was achieved
starting from 6-benzimidazolyl-tri-O-methyl-6-desmethylemodin. The chemical as well as …

Hypericin-mediated photodynamic therapy for the treatment of cancer: a review

X Dong, Y Zeng, Z Zhang, J Fu, L You… - Journal of Pharmacy …, 2021 - academic.oup.com
Objectives Hypericin is a polycyclic aromatic naphthodianthrone that occurs naturally. It is
also an active ingredient in some species of the genus Hypericum. Emerging evidence …

Hypericin in cancer treatment: more light on the way

P Agostinis, A Vantieghem, W Merlevede… - The international journal …, 2002 - Elsevier
Photodynamic therapy (PDT) has been described as a promising new modality for the
treatment of cancer. PDT involves the combination of a photosensitizing agent …