The protein C anticoagulant pathway regulates thrombin formation. The pathway is triggered
when thrombin binds to the endothelial cell proteoglycan, thrombomodulin. Unlike thrombin …

The protein C anticoagulant pathway provides many new insights into control mechanisms
for regulating coagulation. The observation that protein C deficiency is associated with …

For many years, it has been known that the vessel wall presents a nonthrombogenic surface
to the blood. More recently, it has become apparent that the endothelial cells in direct …

Control of the coagulation pathway requires mechanisms that serve to limit and localize the
clotting process. Protein C may serve as one of the major regulatory proteins. It differs from …

The anticoagulant protein C system regulates the activity of coagulation factors VIIIa and Va,
cofactors in the activation of factor X and prothrombin, respectively. Protein C is activated on …

The protein C anticoagulant pathway is recognized as a major control mechanism of blood
coagulation [reviewed in (1)]. Defects in protein C, protein S and thrombomodulin have all …

Protein C is an important regulatory mechanism of blood coagulation. Protein C functions as
an anticoagulant when converted to the active serine protease form on the endothelial cell …

The protein C anticoagulant pathway plays a crucial role as a regulator of the blood clotting
cascade. Protein C is activated on the vascular endothelial cell membrane by the thrombin …

The protein C anticoagulant pathway converts the coagulation signal generated by thrombin
into an anticoagulant response through the activation of protein C by the thrombin …

The endothelial cell protein C receptor@ PCR) is the most recently identified member O {,
the protein C anticoagulant pathway. Protein C and activaibd protein C (APC) bind to EPCR …