Maternal nicotine exposure leads to higher liver oxidative stress and steatosis in adult rat offspring

EP Conceição, N Peixoto-Silva, CR Pinheiro… - Food and Chemical …, 2015 - Elsevier
Early nicotine exposure causes future obesity and insulin resistance. We evaluated the long-
term effect of the maternal nicotine exposure during lactation in liver oxidative status, insulin …

Metabolomic analysis shows differential hepatic effects of T2 and T3 in rats after short-term feeding with high fat diet

LF Iannucci, F Cioffi, R Senese, F Goglia, A Lanni… - Scientific reports, 2017 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is a major health problem worldwide, and is often
associated with lipotoxic injury, defective mitochondrial function, and insulin resistance …

Long-term bisphenol S exposure aggravates non-alcoholic fatty liver by regulating lipid metabolism and inducing endoplasmic reticulum stress response with …

J Qin, S Ru, W Wang, L Hao, Y Ru, J Wang… - Environmental …, 2020 - Elsevier
Environmental chemical exposures have been implicated as risk factors for the development
of non-alcoholic fatty liver (NAFLD). Bisphenol S (BPS), widely used in multitudinous …

Gestational high‐fat diet impaired demethylation of Pparα and induced obesity of offspring

H Pang, D Ling, Y Cheng, R Akbar, L Jin… - Journal of Cellular …, 2021 - Wiley Online Library
Gestational and postpartum high‐fat diets (HFDs) have been implicated as causes of obesity
in offspring in later life. The present study aimed to investigate the effects of gestational …

Exposure to DEHP decreased four fatty acid levels in plasma of prepartum mice

R Nakashima, Y Hayashi, K Md, X Jia, D Wang, H Naito… - Toxicology, 2013 - Elsevier
Maternal exposure to di (2-ethylhexyl) phthalate (DEHP) decreased the plasma triglyceride
in prepartum mice. To identify the fatty acid (FA) species involved and to understand the …

Protective and therapeutic effects of orlistat on metabolic syndrome and oxidative stress in high-fat diet-induced metabolic dysfunction-associated fatty liver disease …

Z Zakaria, ZA Othman, J Bagi Suleiman, NAC Jalil… - Veterinary …, 2021 - mdpi.com
Metabolic dysfunction-associated fatty liver disease (MAFLD) is an excessive buildup of liver
lipids closely associated with various kinds of undesirable metabolic effects and oxidative …

Compound C Protects Mice from HFD‐Induced Obesity and Nonalcoholic Fatty Liver Disease

F Wang, Y Liu, J Yuan, W Yang… - International journal of …, 2019 - Wiley Online Library
Objectives. The aim of this study was to investigate the effects of compound C on an in vivo
mouse model of high‐fat diet‐(HFD‐) induced obesity and hepatosteatosis. Methods …

Obeticholic acid alleviates intrauterine growth restriction induced by di-ethyl-hexyl phthalate in pregnant female mice by improving bile acid disorder

F Zhao, L Zhang, M Qu, L Ye, J Zhang, Y Yu… - … Science and Pollution …, 2023 - Springer
Abstract Di-(2-ethylhexyl)-phthalate (DEHP) is a ubiquitous environmental pollutant and is
widely used in industrial plastics. Intrahepatic cholestasis of pregnancy (ICP), distinguished …

Perinatal maternal high‐fat diet promotes alterations in hepatic lipid metabolism and resistance to the hypolipidemic effect of fish oil in adolescent rat offspring

LS Oliveira, LL Souza, AFP Souza… - Molecular nutrition & …, 2016 - Wiley Online Library
Scope Maternal high‐fat diet (HFD) promotes obesity and metabolic disturbances in
offspring at weaning and adult life. We investigated metabolic consequences of maternal …

Prenatal dexamethasone exposure induces nonalcoholic fatty liver disease in male rat offspring via the miR-122/YY1/ACE2-MAS1 pathway

H Liu, B He, W Hu, K Liu, Y Dai, D Zhang… - Biochemical …, 2021 - Elsevier
Epidemiological studies have shown that nonalcoholic fatty liver disease (NAFLD) has an
intrauterine developmental origin. We aimed to demonstrate that NAFLD is caused by …