Transient receptor potential melastatin 1 (TRPM1) is an ion-conducting plasma membrane channel inhibited by zinc ions

S Lambert, A Drews, O Rizun, TFJ Wagner, A Lis… - Journal of Biological …, 2011 - ASBMB
TRPM1 is the founding member of the melastatin subgroup of transient receptor potential
(TRP) proteins, but it has not yet been firmly established that TRPM1 proteins form ion …

The mammalian melastatin-related transient receptor potential cation channels: an overview

R Kraft, C Harteneck - Pflügers Archiv, 2005 - Springer
The mammalian melastatin-related transient receptor potential (TRPM) subfamily contains
eight members. TRPM proteins, consisting of six putative transmembrane domains and …

Identification and characterization of the murine TRPM4 channel

M Murakami, F Xu, I Miyoshi, E Sato, K Ono… - … and biophysical research …, 2003 - Elsevier
The transient receptor potential (TRP) channels form a superfamily with six transmembrane
structures, which is common in other types of voltage-dependent channels. The TRP …

The selectivity filter of the cation channel TRPM4

B Nilius, J Prenen, A Janssens, G Owsianik… - Journal of Biological …, 2005 - ASBMB
Transient receptor potential channel melastatin subfamily (TRPM) 4 and its close
homologue, TRPM5, are the only two members of the large transient receptor potential …

The TRPM ion channel subfamily: molecular, biophysical and functional features

A Fleig, R Penner - Trends in pharmacological sciences, 2004 - cell.com
Significant progress in the molecular and functional characterization of a subfamily of genes
that encode melastatin-related transient receptor potential (TRPM) cation channels has …

Critical intracellular Ca2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation

D McHugh, R Flemming, SZ Xu, AL Perraud… - Journal of Biological …, 2003 - ASBMB
TRPM2 is a member of the melastatin-related TRP (transient receptor potential) subfamily. It
is expressed in brain and lymphocytes and forms a cation channel that is activated by …

Negatively charged amino acids near and in transient receptor potential (TRP) domain of TRPM4 channel are one determinant of its Ca2+ sensitivity

S Yamaguchi, A Tanimoto, K Otsuguro, H Hibino… - Journal of Biological …, 2014 - ASBMB
Transient receptor potential (TRP) channel melastatin subfamily member 4 (TRPM4) is a
broadly expressed nonselective monovalent cation channel. TRPM4 is activated by …

Identification of direct and indirect effectors of the transient receptor potential melastatin 2 (TRPM2) cation channel

B Tóth, L Csanády - Journal of Biological Chemistry, 2010 - ASBMB
Transient receptor potential melastatin 2 (TRPM2) is a Ca 2+-permeable cation channel
involved in physiological and pathophysiological processes linked to oxidative stress …

Extracellular zinc ion regulates transient receptor potential melastatin 5 (TRPM5) channel activation through its interaction with a pore loop domain

K Uchida, M Tominaga - Journal of Biological Chemistry, 2013 - ASBMB
The transient receptor potential melastatin 5 (TRPM5) channel is a monovalent cation
channel activated by intracellular Ca 2+. Expression of this channel is restricted to taste …

Trafficking and assembly of the cold-sensitive TRPM8 channel

I Erler, DMM Al-Ansary, U Wissenbach… - Journal of Biological …, 2006 - ASBMB
TRPM (transient receptor potential melastatin-like) channels are distinct from many other
members of the transient receptor potential family in regard to their overall size (> 1000 …