Alpha-linolenic acid and its conversion to longer chain n− 3 fatty acids: Benefits for human health and a role in maintaining tissue n− 3 fatty acid levels

G Barceló-Coblijn, EJ Murphy - Progress in lipid research, 2009 - Elsevier
There is little doubt regarding the essential nature of alpha-linolenic acid (ALA), yet the
capacity of dietary ALA to maintain adequate tissue levels of long chain n− 3 fatty acids …

Dietary α-linolenic acid and health-related outcomes: a metabolic perspective

GC Burdge, PC Calder - Nutrition research reviews, 2006 - cambridge.org
α-Linolenic acid (αLNA; 18: 3n-3) is essential in the human diet, probably because it is the
substrate for the synthesis of longer-chain, more unsaturated n-3 fatty acids, principally EPA …

Increased α-linolenic acid intake increases tissue α-linolenic acid content and apparent oxidation with little effect on tissue docosahexaenoic acid in the guinea pig

Z Fu, AJ Sinclair - Lipids, 2000 - Springer
The essential fatty acids do not have identical roles in nutrition. Linoleic acid (LA)
accumulates throughout the body of most mammals, whereas α-linolenic acid (ALA) is rarely …

α-Linolenic acid metabolism in men and women: nutritional and biological implications

G Burdge - Current Opinion in Clinical Nutrition & Metabolic Care, 2004 - journals.lww.com
Overall, α-linolenic acid appears to be a limited source of longer-chain n-3 fatty acids in man
and so adequate intakes of preformed n-3 polyunsaturated fatty acids, in particular …

[HTML][HTML] Health benefits of plant-derived α-linolenic acid

S Rajaram - The American journal of clinical nutrition, 2014 - Elsevier
ABSTRACT α-Linolenic acid (ALA) is an n–3 (ω-3) fatty acid found mostly in plant foods such
as flaxseed, walnuts, and vegetable oils, including canola and soybean oils. Most of the …

What is the role of α‐linolenic acid for mammals?

AJ Sinclair, NM Attar‐Bashi, D Li - Lipids, 2002 - Wiley Online Library
This review examines the data pertaining to an important and often underrated EFA, α‐
linolenic acid (ALA). It examines its sources, metabolism, and biological effects in various …

Dietary α-linolenic acid alters tissue fatty acid composition, but not blood lipids, lipoproteins or coagulation status in humans

DS Kelley, GJ Nelson, JE Love, LB Branch, PC Taylor… - Lipids, 1993 - Springer
We examined the effect of dietary α-linolenic acid (ALA) on the indices of lipid and
coagulation status and on the fatty acid composition of serum and peripheral blood …

[HTML][HTML] Distribution, interconversion, and dose response of n− 3 fatty acids in humans

LM Arterburn, EB Hall, H Oken - The American journal of clinical nutrition, 2006 - Elsevier
ABSTRACT n− 3 Fatty acids have important visual, mental, and cardiovascular health
benefits throughout the life cycle. Biodistribution, interconversion, and dose response data …

[HTML][HTML] The omega-3 fatty acid nutritional landscape: health benefits and sources

RJ Deckelbaum, C Torrejon - The Journal of nutrition, 2012 - Elsevier
Dietary fatty acids (FA) are increasingly recognized as major biologic regulators and have
properties that relate to health outcomes and disease. The longer chain, more bioactive (n …

α‐Linolenic acid metabolism in adult humans: the effects of gender and age on conversion to longer‐chain polyunsaturated fatty acids

GC Burdge, PC Calder - European Journal of Lipid Science …, 2005 - Wiley Online Library
This review summarises and evaluates current knowledge of α‐linolenic acid (αLNA)
metabolism in adult humans. The principal biological role of αLNA appears to be as a …