Background To evaluate the characteristics of the tumor immune-microenvironment in brain
metastases of non-small-cell lung cancer (NSCLC), we investigated the immunophenotype …

Background Dissemination of non–small-cell lung cancer (NSCLC) in the central nervous
system is a frequent and challenging clinical problem. Systemic or local therapies rarely …

Background The tumor immune microenvironment (TIME) of lung cancer brain metastasis is
largely unexplored. We carried out immune profiling and sequencing analysis of paired …

Lung cancer is one of the most common causes of brain metastases and is always
associated with poor prognosis. We investigated the immunophenotypes of primary lung …

Background Previous studies found that lung adenocarcinomas (LUAD) with EGFR-positive
and ALK-positive were less responsive to immunotherapy, which may be associated with a …

Brain metastasis (BM), a devastating complication of advanced malignancy, has a high
incidence in non-small cell lung cancer (NSCLC). As novel systemic treatment drugs and …

Brain metastasis (BM) is a common malignant event in lung cancer. Here, we recruited 33
lung cancer patients with brain oligo-metastasis to explore the genomic features and tumor …

Background Only certain disseminated cells are able to grow in secondary organs to create
a metastatic tumor. Under the hypothesis that the immune microenvironment of the host …

Brain metastases (BrMs) are the most common form of brain tumors in adults and frequently
originate from lung and breast primary cancers. BrMs are associated with high mortality …

Methods We used single-cell transcriptome sequencing and multiplex
immunohistochemistry to investigate the immune microenvironment of EGFR-mutant and …