Given the critical involvement of reactive oxygen species (ROS) in cell death, their
hierarchical status in the cell pathway has been analyzed by many investigators. However, it …

Reactive oxygen species (ROS) and mitochondria play an important role in apoptosis
induction under both physiologic and pathologic conditions. Interestingly, mitochondria are …

We investigated the role of the caspase activation cascade in apoptosis induced by ionizing
radiation or hydrogen peroxide (H 2 O 2) in human leukemia HL60 cells. Electron …

Purpose: This review is focused on the potential impact of low dose radiation effects on
intercellular induction of apoptosis and the underlying reactive-oxygen species (ROS) …

Mitochondria play central roles in cellular metabolism and apoptosis and are a major source
of reactive oxygen species (ROS). We investigated the role of ROS and mitochondria in …

Reactive oxygen species (ROS) are produced as a by-product of cellular metabolic
pathways and function as a critical second messenger in a variety of intracellular signaling …

The function of bcl‐2 in preventing cell death is well known, but the mechanisms whereby
bcl‐2 functions are not well characterized. One mechanism whereby bcl‐2 is thought to …

Reactive oxygen species (ROS) and caspases have been implicated as potential mediators
of cell death. However, their mechanistic relationship remains to be elucidated. Here we …

Since radiation-induced caspase-dependent apoptosis and ROS generation were partially
prevented by HSP25 overexpression, similar to the treatment of control cells with antioxidant …

Recently, we showed that hypoxia/reoxygenation (H/R) induced apoptosis in human
lymphocytes via reactive oxygen species (ROS) generation and disruption of the …