Abstract P-glycoprotein (P-gp) function of leukemic blasts is associated with chemotherapy
resistance in acute myeloid leukemia (AML). The C3435T polymorphism in the human …

We investigated the association between the MDR1 C3435T polymorphism and P-
glycoprotein function of leukemic blasts as well as clinical outcomes in 200 patients with …

MDRâ•’1 C3435T gene polymorphism does not correlate with Pâ•’Glycoprotein expression
and function in acute myeloid leu Page 1 CLINICAL PHAP-dMACOLO(iY & THERAPEUTICS …

Multidrug‐resistance (MDR) phenotype is a serious limitation to the effective
chemotherapeutic treatment of many cancer types, including leukemia. One of the most …

The multidrug resistance (MDR1) gene product P-glycoprotein is a membrane bound protein
that functions as an ATP-dependent efflux pump, transporting exogenous and endogenous …

Allelic variants of the MDR-1 gene have been shown recently to influence protein
expression and P-glycoprotein (P-gp) function in healthy volunteers. Therefore, 405 acute …

Abstract Multidrug resistance‐1 (MDR‐1) gene single nucleotide polymorphisms (SNPs)
have been identified as associated with the treatment outcomes of acute myeloid leukemia …

BACKGROUND: The expression of the multidrug resistance-1 (MDR-1) gene which encodes
p-glycoprotein, is recognized as a biological mechanism possibly contributing to treatment …

6550 Background: Multidrug resistance (MDR) is one of the important mechanisms of
treatment failure of acute myeloid leukemia (AML). Recently, MDR-1 gene single nucleotide …

Objective To assess the correlation of the multidrug resistance-1 (MDR1) gene single
nucleotide polymorphisms (SNP) C1236T, G2677T/A and C3435T with the outcome of …