Chemoresistance against multiple anti-cancer drug regimens being reported in acute
lymphoblastic leukemia (ALL) is one of the major therapeutic concerns against the refractory …

Background: P-glycoprotein (P-gp) is a transmembrane pump encoded by MDR1 gene. It
contributes in protection of the cells against xenobiotic and toxic compounds. P-gp also …

Abstract P-glycoprotein (P-gp), a membrane transporter encoded by multidrug resistance 1
(MDR1) gene, influences pharmacokinetics of anticancer drugs and contributes to multidrug …

Sequence variation at the proximal MDR1 promoter of 72 patients with acute myeloid
leukemia (AML) was investigated and its association with P-glycoprotein (Pgp) expression …

Multidrug resistance is an important mechanism responsible for refractoriness of leukemia
and worse outcome of patients. Overexpression of the multidrug resistance gene, MDR1, is …

P-glycoprotein (P-gp), a membrane transporter encoded by MDR1 gene, influences
pharmacokinetics of anti-cancer drugs and contributes to multi-drug resistance phenotype in …

Multidrug resistance is a common form of drug resistance of tumors and one main reason for
chemotherapy′ s failure and recrudescence of acute leukemia. In recent years, substantial …

The expression of P-glycoprotein (P-gp), encoded by the MDR 1 gene, is an independent
adverse prognostic factor for response and survival in de novo Acute Myeloid Leukemia …

Introduction: The significance of genetic background in acute lymphoblastic leukemia (ALL)
is not well understood. Polymorphism of genes encoding xenibiotics and drug transporters …

Background: The frequency of the multi-drug resistance 1 (MDR1) gene C3435T
polymorphism differs in various ethnical populations such as Asian, African, and Caucasians …