In an attempt to determine the incidence and clinical relevance of mdr1 gene expression in
acute myeloid leukemia (AML), we examined 126 specimens obtained from adult patients …

An important number of patients with Acute Myeloid Leukemia (AML) experience relapse or
resistance to chemotherapy. One of the mechanisms involved in this resistance is the …

CiNii 博士論文 - Expression of the multidrug resistance gene in myeloid leukemia : clinical
significance of the mdr1 transcript level as an indication of resistant disease in acute …

P-glycoprotein (P-gp) is often expressed (40-50%) on leukemic cells at diagnosis in acute
myelogenous leukemia (AML), and is even more frequently present after treatment failure …

Objective Our objective was to investigate the effect of single nucleotide polymorphisms
(SNPs) in the P‐glycoprotein MDR1 gene on vincristine pharmacokinetics and side effects in …

The induced expression of multiple drug resistance (MDR)-associated genes as a direct
response of tumor cells to antineoplastic drugs could be an important factor influencing the …

Overexpression of P-glycoprotein (Pgp) or MDR1 mRNA has been shown to be a negative
prognostic factor for clinical outcome in acute myeloid leukemia (AML). However, resistance …

We appreciated the review on multidrug resistance (MDR) in leukemia by Haber,'and we
wish to contribute to the issue by bringing to attention our prospective study of the …

BACKGROUND: The multidrug resistance (MDR1) gene's polymorphism affects the
metabolism andpharmacokinetics of chemotherapeutic agents and smooth drug resistance …