Population pharmacokinetics and safety of piperacillin-tazobactam extended infusions in infants and children
C Thibault, J Lavigne, C Litalien, N Kassir… - Antimicrobial agents …, 2019 - Am Soc Microbiol
Piperacillin-tazobactam (TZP) is frequently used to treat severe hospital-acquired infections
in children. We performed a single-center, pharmacokinetic (PK) trial of TZP in children …
in children. We performed a single-center, pharmacokinetic (PK) trial of TZP in children …
Population pharmacokinetics and pharmacodynamics of extended-infusion piperacillin and tazobactam in critically ill children
K Nichols, EK Chung, CA Knoderer… - Antimicrobial agents …, 2016 - Am Soc Microbiol
The study objective was to evaluate the population pharmacokinetics and
pharmacodynamics of extended-infusion piperacillin-tazobactam in children hospitalized in …
pharmacodynamics of extended-infusion piperacillin-tazobactam in children hospitalized in …
Dose optimization of piperacillin/tazobactam in critically ill children
PAJG De Cock, SC Van Dijkman… - Journal of …, 2017 - academic.oup.com
Objectives: To characterize the population pharmacokinetics of piperacillin and tazobactam
in critically ill infants and children, in order to develop an evidence-based dosing regimen …
in critically ill infants and children, in order to develop an evidence-based dosing regimen …
Optimising piperacillin/tazobactam dosing in paediatrics
CW Tornøe, JJ Tworzyanski, MA Imoisili… - International journal of …, 2007 - Elsevier
Piperacillin/tazobactam, an intravenous antibacterial combination product, has recently
been approved for paediatric (age 2 months to 17 years) use in the USA. The purpose of this …
been approved for paediatric (age 2 months to 17 years) use in the USA. The purpose of this …
Population pharmacokinetics of piperacillin/tazobactam in critically ill young children
JJ Cies, V Shankar, C Schlichting… - The Pediatric infectious …, 2014 - journals.lww.com
Methods: Blood samples (2–4 per child) were collected from 13 children ages 9 months to 6
years admitted to the pediatric intensive care unit who were receiving standard piperacillin …
years admitted to the pediatric intensive care unit who were receiving standard piperacillin …
Population pharmacokinetics of piperacillin/tazobactam in neonates and young infants
Z Li, Y Chen, Q Li, D Cao, W Shi, Y Cao, D Wu… - European journal of …, 2013 - Springer
Objectives To develop population pharmacokinetic (PK) models for piperacillin/tazobactam
in neonates and infants of less than 2 months of age in order to determine the appropriate …
in neonates and infants of less than 2 months of age in order to determine the appropriate …
System-wide implementation of the use of an extended-infusion piperacillin/tazobactam dosing strategy: feasibility of utilization from a children's hospital perspective
KR Nichols, CA Knoderer, EG Cox, MB Kays - Clinical therapeutics, 2012 - Elsevier
BACKGROUND: Use of extended infusions of piperacillin/tazobactam (PT) in adult patients
has been described, but data in children are limited. OBJECTIVE: The goal of this study was …
has been described, but data in children are limited. OBJECTIVE: The goal of this study was …
Target attainment analysis and optimal sampling designs for population pharmacokinetic study on piperacillin/tazobactam in neonates and young infants
Y Chen, J Lu, M Dong, D Wu, Y Zhu, Q Li… - European journal of …, 2016 - Springer
Objectives Population pharmacokinetic (popPK) analyses for piperacillin/tazobactam in
neonates and infants of less than 2 months of age have been performed by our group …
neonates and infants of less than 2 months of age have been performed by our group …
Single-dose pharmacokinetics of piperacillin and tazobactam in infants and children
MD Reed, J Goldfarb, TS Yamashita… - Antimicrobial agents …, 1994 - Am Soc Microbiol
The pharmacokinetics of piperacillin and tazobactam were assessed after single-dose
administration to 47 infants and children. Study subjects ranging in age from 2 months to 12 …
administration to 47 infants and children. Study subjects ranging in age from 2 months to 12 …
Extended infusion of piperacillin/tazobactam in children
CA Knoderer, LC Karmire… - The Journal of …, 2017 - meridian.allenpress.com
OBJECTIVES Extended-infusion piperacillin/tazobactam (TZP) has been associated with
positive clinical outcomes in adults, but similar data in children are lacking. The objective of …
positive clinical outcomes in adults, but similar data in children are lacking. The objective of …