RECAST (remote ischemic conditioning after stroke trial) a pilot randomized placebo controlled phase II trial in acute ischemic stroke

TJ England, A Hedstrom, S O'Sullivan, R Donnelly… - Stroke, 2017 - Am Heart Assoc
Background and Purpose—Repeated episodes of limb ischemia and reperfusion (remote
ischemic conditioning [RIC]) may improve outcome after acute stroke. Methods—We …

A review of remote ischemic conditioning as a potential strategy for neural repair poststroke

W Yu, C Ren, X Ji - CNS Neuroscience & Therapeutics, 2023 - Wiley Online Library
Ischemic stroke is one of the major disabling health‐care problem and multiple different
approaches are needed to enhance rehabilitation, in which neural repair is the structural …

Remote ischemic conditioning as an additional treatment for acute ischemic stroke: the preclinical and clinical evidence

TRJ Landman, Y Schoon, MC Warlé, FE de Leeuw… - Stroke, 2019 - Am Heart Assoc
Methods A formal systematic review was not performed because of the heterogeneity of the
studies and recently published systematic reviews on preclinical 12 and clinical studies. 13 …

Remote ischemic conditioning reduced cerebral ischemic injury by modulating inflammatory responses and ERK activity in type 2 diabetic mice

C Liu, J Yang, C Zhang, X Geng, H Zhao - Neurochemistry International, 2020 - Elsevier
Remote ischemic preconditioning (RIPreC) and postconditioning (RIPostC) have been
demonstrated to attenuate brain injury after ischemic stroke in healthy animals. This study …

Acute remote ischemic preconditioning alleviates free radical injury and inflammatory response in cerebral ischemia/reperfusion rats

XL Meng, DL Zhang, SH Sui - Experimental and …, 2019 - spandidos-publications.com
Remote ischemic preconditioning (IPreC) is an effective strategy to defend against cerebral
ischemia/reperfusion (IR) injury; however, its mechanisms remain to be elucidated. The aim …

Remote ischemic perconditioning in thrombolysed stroke patients: randomized study of activating endogenous neuroprotection–design and MRI measurements

KD Hougaard, N Hjort, D Zeidler… - … Journal of Stroke, 2013 - journals.sagepub.com
Background Intravenous administration of alteplase is the only approved treatment for acute
ischemic stroke. Despite the effectiveness of this treatment, 50% of patients suffer chronic …

Splenic responses play an important role in remote ischemic preconditioning-mediated neuroprotection against stroke

C Chen, W Jiang, Z Liu, F Li, J Yang, Y Zhao… - Journal of …, 2018 - Springer
Background Remote ischemic preconditioning (RIPC) of a limb has been reported to protect
against ischemic stroke. Our previous results demonstrated that the RIPC-mediated …

Remote ischemic conditioning in the treatment of acute cerebral infarction: A case control study

Q Zeng, P Huang, Z Wang, L Wei, K Lin - Heliyon, 2023 - cell.com
Objective This paired case-control study aimed to evaluate the efficacy and safety of remote
ischemic conditioning (RIC) in patients with acute cerebral infarction (CI) and explore …

The chronic protective effects of limb remote preconditioning and the underlying mechanisms involved in inflammatory factors in rat stroke

D Wei, C Ren, X Chen, H Zhao - PloS one, 2012 - journals.plos.org
We recently demonstrated that limb remote preconditioning (LRP) protects against focal
ischemia measured 2 days post-stroke. Here, we studied whether LRP provides long-term …

Remote ischemic conditioning for stroke: clinical data, challenges, and future directions

W Zhao, S Li, C Ren, R Meng, K Jin… - Annals of clinical and …, 2019 - Wiley Online Library
Despite great improvement during the past several decades, the management of stroke is
still far from satisfactory, which warrants alternative or adjunctive strategies. Remote …