The angiotensin converting enzyme 2/Ang-(1-7) axis in the heart: a role for mas communication?

JA Stewart Jr, E Lazartigues, PA Lucchesi - Circulation research, 2008 - Am Heart Assoc
For decades, the literature has been inundated with evi-dence of the important role of the
renin–angiotensin system (RAS) in cardiac remodeling and function with most in the field …

ACE and ACE2: a tale of two enzymes

LS Zisman - European heart journal, 2005 - academic.oup.com
The cardiac renin–angiotensin–aldosterone system (RAAS) is an endocrine cascade, which
results in the conversion of the inactive pro-hormone angiotensin I (Ang I) to the active …

[HTML][HTML] An ACE in the hole: Alternative pathways of the renin angiotensin system and their potential role in cardiac remodeling

B Greenberg - Journal of the American College of Cardiology, 2008 - jacc.org
There is compelling evidence that the renin angiotensin system (RAS) plays a major role
both in maintaining cardiovascular homeostasis and the pathogenesis of cardiovascular …

Angiotensin-(1–7) and angiotensin-(1–9): function in cardiac and vascular remodelling

CA McKinney, C Fattah, CM Loughrey… - Clinical …, 2014 - portlandpress.com
The RAS (renin–angiotensin system) is integral to cardiovascular physiology; however,
dysregulation of this system largely contributes to the pathophysiology of CVD …

The angiotensin-(1-7) axis: formation and metabolism pathways

MC Chappell - Angiotensin-(1-7) A Comprehensive Review, 2019 - Springer
The renin-angiotensin system (RAS) constitutes a key hormonal system in the physiological
regulation of blood pressure via peripheral and central mechanisms. Dysregulation of the …

Heterozygote loss of ACE2 is sufficient to increase the susceptibility to heart disease

W Wang, VB Patel, N Parajuli, D Fan, R Basu… - Journal of molecular …, 2014 - Springer
Abstract Angiotensin-converting enzyme 2 (ACE2) metabolizes Ang II into Ang 1–7 thereby
negatively regulating the renin-angiotensin system. However, heart disease in humans and …

Working outside the system: an update on the unconventional behavior of the renin–angiotensin system components

M Kurdi, WC De Mello, GW Booz - … journal of biochemistry & cell biology, 2005 - Elsevier
The renin–angiotensin system (RAS) plays an important role in regulating arterial pressure,
blood volume, thirst, cardiac function, and cellular growth. Both a circulating and multiple …

[HTML][HTML] The ACE2/angiotensin-(1–7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1–7)

RAS Santos, WO Sampaio, AC Alzamora… - Physiological …, 2017 - journals.physiology.org
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

Regulation of ACE2 in cardiac myocytes and fibroblasts

PE Gallagher, CM Ferrario… - American Journal of …, 2008 - journals.physiology.org
Angiotensin-converting enzyme 2 (ACE2) preferentially forms angiotensin-(1-7)[ANG-(1-7)]
from ANG II. We showed that cardiac ACE2 is elevated following treatment of coronary artery …

[PDF][PDF] Angiotensin-converting enzyme 2, angiotensin-(1-7) and Mas: new players of the renin-angiotensin system

RA Santos, AJ Ferreira, T Verano-Braga, M Bader - J endocrinol, 2013 - academia.edu
Abstract Angiotensin (Ang)-(1–7) is now recognized as a biologically active component of
the renin–angiotensin system (RAS). Ang-(1–7) appears to play a central role in the RAS …