Neurosensory disorders such as pain and pruritus remain a major health problem greatly
impacting the quality of life, and often increasing the risk of mortality. Current pre-clinical …

There is growing evidence for functional interactions between nociceptive nerve endings
and non-neuronal cells modulating sensory function in health and disease. In the skin, non …

In vitro models fill a vital niche in preclinical pain research, allowing detailed study of
molecular pathways, and in the case of humanised systems, providing a translational bridge …

Despite the significant global prevalence of chronic pain, current methods to identify pain
therapeutics often fail translation to the clinic. Phenotypic screening platforms rely on …

A critical role of the peripheral axons of nociceptors of the dorsal root ganglion (DRG) is the
conduction of all-or-nothing action potentials from peripheral nerve endings to the central …

Background Dorsal root ganglion neuron-derived immortal cell lines including ND7/23 and F-
11 cells have been used extensively as in vitro model systems of native peripheral sensory …

Background A wide range of stimuli can activate sensory neurons and neurons innervating
specific tissues often have distinct properties. Here, we used retrograde tracing to identify …

Chronic neuropathic pain is a major morbidity of neural injury, yet its mechanisms are
incompletely understood. Hypersensitivity to previously non-noxious stimuli (allodynia) is a …

The high prevalence of pain and the at times low efficacy of current treatments represent a
significant challenge to healthcare systems worldwide. Effective treatment strategies require …

In vitro models of the peripheral nervous system would benefit from further refinements to
better support studies on neuropathies. In particular, the assessment of pain-related signals …