The function of the m6A methyltransferase METTL3 in goat early embryo development under hypoxic and normoxic conditions

D Li, Z Liu, M Deng, L Liu, J Lu, F Wang, Y Wan - Theriogenology, 2022 - Elsevier
It has been reported that N6-methyladenosine (m6A) methyltransferase-like 3 (METTL3)
plays an important role in zygote genome activation during embryonic development, but the …

18S ribosomal RNA methyltransferase METTL5-mediated CDX2 translation regulates porcine early embryo development1

T XU, M ZHANG, Q LIU, W Xin, P LUO, LIU Tong… - Journal of Integrative …, 2023 - Elsevier
Abstract N6-methyladenosine (m6A) plays a key role in mammalian early embryonic
development and cell lineage differentiation. However, the role and mechanisms of 18S …

Involvement of METTL3-mediated m6A methylation in the early development of porcine cloned embryos

M Zhang, X Wu, T Guo, Y Xia, Z Wang, Z Shi, K Hu… - Theriogenology, 2024 - Elsevier
Abstract METTL3-mediated N6-methyladenosine (m6A) modification is critical for
gametogenesis and early embryonic development. However, the function of METTL3 …

METTL3-mediated m6A methylation negatively modulates autophagy to support porcine blastocyst development

Z Cao, L Zhang, R Hong, Y Li, Y Wang… - Biology of …, 2021 - academic.oup.com
Abstract N6-methyladenosine (m6A) catalyzed by METTL3 regulates the maternal-to-zygotic
transition in zebrafish and mice. However, the role and mechanism of METTL3-mediated …

METTL3 promotes proliferation of goat endometrial epithelial cells by regulating CTGF in an m6A-dependent manner

Y Sun, XC Zhang, MD Li, LG Bu, B Wang… - Biology of …, 2023 - academic.oup.com
Abstract N6-methyladenosine (m6A), an epigenetic modification on RNAs, plays an
important role in many physiological and pathological processes. However, the involvement …

High Temperature–Induced m6A Epigenetic Changes Affect Early Porcine Embryonic Developmental Competence in Pigs

MH Sun, WJ Jiang, XH Li, SH Lee, G Heo… - Microscopy and …, 2023 - academic.oup.com
Abstract N6-methyladenosine (m6A), the most prevalent modification in eukaryotic
messenger RNA (mRNA), plays a key role in various developmental processes in mammals …

N6‐methyladenosine methyltransferase METTL3 modulates the cell cycle of granulosa cells via CCND1 and AURKB in Haimen goats

Z Liu, L Zhou, D Li, H Lu, L Liu, W Mao, X Yu… - The FASEB …, 2023 - Wiley Online Library
Abstract N6‐methyladenosine (m6A) plays a crucial role in many bioprocesses across
species, but its function in granulosa cells during oocyte maturation is not well understood in …

Dynamic reprogramming and function of RNA N6-methyladenosine modification during porcine early embryonic development

T Yu, X Qi, L Zhang, W Ning, D Gao, T Xu, Y Ma… - Zygote, 2021 - cambridge.org
N6-Methyladenosine (m6A) regulates oocyte-to-embryo transition and the reprogramming of
somatic cells into induced pluripotent stem cells. However, the role of m6A methylation in …

Inhibition of METTL5 improves preimplantation development of mouse somatic cell nuclear transfer embryos

L Zhang, M Yuan, X Huang, Q Cao, S Huang… - …, 2022 - rep.bioscientifica.com
In brief Several factors affect the reprogramming efficiency of nuclear transfer embryos. This
study shows that inhibiting 18S rRNA m 6 A methyltransferase METTL5 during nuclear …

METTL3-mediated m6A is required for murine oocyte maturation and maternal-to-zygotic transition

X Sui, Y Hu, C Ren, Q Cao, S Zhou, Y Cao, M Li… - Cell Cycle, 2020 - Taylor & Francis
ABSTRACT N6-methyladenosine (m6A) is the most prevalent epigenetic modification of
messenger RNA (mRNA) in higher eukaryotes; this modification is mainly catalyzed by a …