1, 25 (OH) 2D3 activates autophagy to protect against oxidative damage of INS-1 pancreatic beta cells

D He, Y Wang, R Liu, A He, S Li, X Fu… - Biological and …, 2019 - jstage.jst.go.jp
Diabetes mellitus is a serious disease endangering human health worldwide. Vitamin D (Vit
D) is a well-characterized regulator of calcium-phosphorus metabolism that also exerts other …

[HTML][HTML] Vitamin D induces autophagy of pancreatic β-cells and enhances insulin secretion

Y Wang, D He, C Ni, H Zhou… - Molecular …, 2016 - spandidos-publications.com
Epidemiological evidence indicates that vitamin D is involved in defense against diabetes;
however, the precise underlying mechanism remains to be elucidated. In the present study …

[HTML][HTML] Vitamin D regulates insulin and ameliorates apoptosis and oxidative stress in pancreatic tissues of rats with streptozotocin-induced diabetes

FEZM Fathi, KM Sadek, AF Khafaga… - … Science and Pollution …, 2022 - Springer
This study was designed to evaluate the potential therapeutic efficacy of vitamin D (Vit D) in
averting the harmful effects of type 2 diabetes mellitus (T2D). Forty male Wistar rats were …

[HTML][HTML] Vitamin D alleviates type 2 diabetes Mellitus by mitigating oxidative stress-Induced pancreatic β-Cell impairment

J Liu, Y Zhang, D Shi, C He… - Experimental and Clinical …, 2023 - thieme-connect.com
Objective Type 2 diabetes mellitus (T2DM) is a common metabolic disorder with rising
incidence worldwide. This study explored the anti-T2DM role of vitamin D, thereby providing …

1α, 25 (OH)(2) D (3) protects pancreatic β-cell line from cytokine-induced apoptosis and impaired insulin secretion

AP Wang, X Li, C Chao, G Huang, BL Liu… - Zhonghua yi xue za …, 2012 - europepmc.org
Objective To explore the protective effects and potential mechanisms of 1α, 25 (OH)(2) D
(3)(VitD (3)) on pancreatic β-cells. Methods The apoptosis of NIT-1 cells was induced by …

1, 25 (OH) 2D3 protects β cell against high glucose-induced apoptosis through mTOR suppressing

Z Yang, F Liu, H Qu, H Wang, X Xiao, H Deng - Molecular and cellular …, 2015 - Elsevier
Diabetes mellitus is a leading cause of death and disability worldwide, which presents a
serious public health crisis in China nowadays. It has been well recognized that excessive β …

1,25-(OH)2D3 protects pancreatic beta cells against H2O2-induced apoptosis through inhibiting the PERK-ATF4-CHOP pathway

X Hu, C Hu, J Liu, Z Wu, T Duan… - Acta Biochimica et …, 2021 - academic.oup.com
Endoplasmic reticulum (ER) stress plays a critical role in pancreatic β cell destruction which
leads to the pathogenesis of type 1 diabetes mellitus (T1DM). Vitamin D (VD) has been …

Autophagy participates in the protection role of 1, 25‐dihydroxyvitamin D3 in acute myocardial infarction via PI3K/AKT/mTOR pathway

YX Wei, SM Dong, YY Wang, P Zhang… - Cell biology …, 2021 - Wiley Online Library
Vitamin D deficiency is associated with acute myocardial infarction (AMI); thus we aimed to
explore improvement effects of 1, 25‐dihydroxyvitamin D3 (VD3) on the AMI and its potential …

[HTML][HTML] Vitamin D ameliorates podocyte injury by enhancing autophagy activity in diabetic kidney disease

X Zhang, L Zhang, Y Wen, M Zhang, S Liu… - Kidney and Blood …, 2023 - karger.com
Introduction: Restoration of podocyte autophagy is considered as a feasible strategy for the
treatment of diabetic kidney disease (DKD). This study aimed at investigating the protective …

Vitamin D3 improves lipophagy-associated renal lipid metabolism and tissue damage in diabetic mice

H Lee, H Lee, Y Lim - Nutrition Research, 2020 - Elsevier
Oxidative stress and abnormal lipid metabolism in diabetes can trigger renal lipotoxicity,
extending to diabetic nephropathy. Vitamin D 3 has been known to be involved in lipid …